As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.
Preparation 1064-Benzo[b]thiophen-7-yl-3-methoxymethoxy -pyridine Solution A: Treat a solution of 3 -methoxymethoxy -pyridine (2.5 g, 18 mmol) in diethyl ether (90 mL) at -70 0C with tert-butyl lithium (1.7 M in pentane, 10 mL, 18 mmol) dropwise over 10 min. Stir the mixture at -70 0C for 40 min and add a solution of triisopropyl borate (5 mL, 22 mmol) in THF (10 mL) dropwise over 5 min. Stir the mixture at -70 0C for 1 h and then remove the ice bath and allow the mixture to slowly warm to RT. Solution B: Treat a solution of 7-bromo-benzo[b]thiophene (3.8 g, 18 mmol), 2- (di-tert-butylphosphino)biphenyl (268 mg, 0.90 mmol), Pd(dppf)Cl2 (732 mg, 0.90 mmol) in 1,4-dioxane (30 mL) with 2 M aqueous sodium carbonate (72 mL, 36 mmol). Heat the solution to 80 0C once solution A reaches RT. Treat solution B with solution A dropwise over 10 min. Heat the combined solution to 85 0C for 5 h. Cool the mixture to RT and dilute with ethyl acetate and water. Wash the organic phase with water and aqueous saturated sodium chloride, dry over sodium sulfate, filter, and concentrate in vacuo. Purify the residue by column chromatography on 12O g silica gel eluting with a gradient of DCM to ethyl acetate to give the title compound (3.8 g) containing some starting 3-methoxymethoxy-pyridine. 1H NMR (400 MHz, CDCl3) delta 8.68 (s, IH), 8.42 (d, J= 4 Hz, IH), 7.88 (d, J= 8 Hz, IH), 7.33-7.50 (m, 5H), 5.12 (s, 2H), 3.36 (s, 3H)., 1423-61-6
As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2008/144222; (2008); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem