4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
j00348j To a solution of 5-bromobenzo[bjthiophene (2.0 g, 9.4 mmol) in tetrahydrofuran (20 mL)at -70C under nitrogen was added dropwise lithium diisopropylamide (2 M in tetrahydrofuran, 5.6mL, 11 mmol). The solution was stirred at -70C for 1 hour, and then iodomethane (2.0 g, 14mmol) was added. The resulting solution was stirred at -70C for 2 hours and at room temperature foranother 13 hours, then poured into 5% hydrochloric acid (100 mL) and extracted with ethyl acetate (2x 100 mL). The combined organic layers were washed with aqueous sodium bicarbonate (2 x 30 mL)and concentrated in vacuo. The residue was purified by flash column chramotagraphy [100%petroleum etherj to give compound B-38 (1.9 g, 89% yield) as a white solid. 1H-NMR (CDC13, 400MHz): 7.80 (d, J=2.0 Hz, 1H), 7.61 (d, J=8.4 Hz, 1H), 7.36 (dd, J18.4 Hz, J21.6 Hz, 1H), 6.93 (s,1H), 2.61 (s, 3H)
4923-87-9, As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.
Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem