With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.
General procedure: Pd(OAc)2 (0.025 mmol, 5.6 mg), PCy¡¤HBF4 (0.05 mmol,18.5 mg), 1a (0.25 mmol, 45.5 mg), and KOtBu (0.75 mmol,84 mg) were added to a Schlenk 8ask. And the mixture wasdissolved in 1 mL of toluene under a nitrogen atmosphere.*e reaction mixture was stirred at 110C for 24 h. *en,ethyl acetate was used to dissolve the mixtupe as much aspossible (except for inorganic salt). Celatom was used to;lter undissolved substance. After this, the solvent wasevaporated under vacuum and the mixture was analyzed byGC or puri;ed by column chromatography on silica gel(petpoleum ethep: ethyl aceta3te:1) to a5ord product 1cas a pale yellow solid.
1127-35-1, 1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Article; Liu, Hailong; Li, Wenjing; Fu, Haiyan; Chen, Hua; Li, Ruixiang; Li, Yu; Journal of Chemistry; vol. 2019; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem