With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
5381-20-4, General procedure: The reaction was performed in a 20 mL V-type tube equipment with a triangle magnetic stirring bar. In a typical reaction, 4-hydroxyindole (0.4 mmol) was mixed with malonodinitrile (0.4 mmol) and aldehydes (0.4 mmol) in 2.0 mL of ethanol. KF (0.08 mmol) was then added. The mixture was subsequently heated to 60 C under stirring for 6 h. After the reaction, the mixture was cooled to room temperature, and the target product was isolated using a preparative thin-layer chromatograph (TLC) with eluting solution [petroleum ether/ethyl acetate 3/1 (v/v)].
5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Article; Bai, Rongxian; Yang, Jian; Min, Lijun; Liu, Changhui; Wu, Fengtian; Gu, Yanlong; Tetrahedron; vol. 72; 17; (2016); p. 2170 – 2177;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem