Day: October 12, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

To a mixture of benzo[b]thiophene-2-carbaldehyde (3 g, 18.6 mmol) and core 1 (4 g, 12.4 mmol) in anhydrous CH3CN (100 mL) was added TFA (424 mg, 3.7 mmol) at 25C. The mixture was agitated for 6 hours. The reaction mixture became a clear solution and then a solid appeared. The solid was collected by filtration and washed with CH3CN to provide 9a (5.4 g, 69 % yield)., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; TONG, Ling; YU, Wensheng; KOZLOWSKI, Joseph A.; CHEN, Lei; SELYUTIN, Oleg; KIM, Seong Heon; DWYER, Michael; HU, Bin; ZHONG, Bin; WAI, Dahai; HAO, Jinglai; SHEN, Changmao; LEI, Zhixin; WANG, Weijun; WO2014/110706; (2014); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

6314-28-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Reference example 188; 1-[(2-Benzothienylcarbonyl)amino]cyclohexanecarboxylic acid phenylmethyl ester [Show Image] Under ice-cooling, 5.9 g (31 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride was added to a solution of 5 g (28 mmol) of 2-benzothiophenecarboxylic acid, 6.5 g (28 mmol) of 1-aminocyclohexanecarboxylic acid phenylmethyl ester and 4.5 g (29 mmol) of 1-hydroxybenzotriazole in methylenechloride. After the mixture was stirred at room temperature overnight, the reaction solvent was distilled off under reduced pressure. Water was added to the residue and the mixture was extracted with ethyl acetate twice. The obtained organic layer was washed with a 10% aqueous potassium hydrogensulfate solution, a saturated aqueous sodium hydrogencarbonate solution, and then saturated brine, followed by drying with anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and diethyl ether was added to the obtained residue, followed by stirring of the mixture overnight. The cystal was collected by filtration and was heated and dried under reduced pressure to obtain 10 g (91%) of the title compound. 1H-NMR (CDCl3, delta): 1.25-1.78 (6H, m), 1.93-2.05 (2H, m), 2.12-2.25 (2H, m), 5.18 (2H, s), 6.24 (1H, s), 7.20-7.38 (5H, m), 7.38-7.51 (2H, m), 7.77 (1H, s), 7.80-7.91 (2H, m)

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

Reference£º
Patent; SEIKAGAKU CORPORATION; EP1972615; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, The intermediate 1- (3,4,5-trimethoxyphenyl) propan-1-one (448 mg, 2 mmol) and benzo [b] thiophene-3-carboxaldehyde (162.2 mg, 1 mmol) were dissolved in ethanol (8 mL ) solution,Stir at room temperature for 30min,Then add sodium hydroxide (3mL) until the reaction is complete, extract with CH2Cl2, wash with saturated sodium chloride solution, dry over anhydrous sodium sulfate, filter, spin dry the organic phase,The remaining crude product was recrystallized from ethanol to obtain the target compound (E)-3-(benzo[b]thiophen-3-yl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 206.1 mg, 56% yield.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ningxia Medical University; Zhuang Chunlin; Shi Ying; Cong Hui; Zhang Wannian; Huang Jiaxuan; Yu Jianqiang; Xu Lijuan; Qu Zhuo; (21 pag.)CN110526854; (2019); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5381-20-4

General procedure: An aqueous solution of NaOH (3M, 1.6mL) was added to a solution of aromatic ketone (1mmol) and 3-methoxybenzaldehyde (1.2 eq), in EtOH (1-2mL). The reaction was stirred at r.t for 18-24h. The reaction mixture was cooled in an ice-water bath and acidified to pH 2 with concentrated HCl (37%). The solid formed was filtered, washed with ethanol and then further purified by recrystallization from ethanol. When no precipitate occurred, the reaction mixture was extracted with dichloromethane and washed with water and brine. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. Column chromatography was then utilized to purify the desired product.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Borsari, Chiara; Jimenez-Anton, Maria Dolores; Eick, Julia; Bifeld, Eugenia; Torrado, Juan Jose; Olias-Molero, Ana Isabel; Corral, Maria Jesus; Santarem, Nuno; Baptista, Catarina; Severi, Leda; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Reinshagen, Jeanette; Witt, Gesa; Linciano, Pasquale; Tait, Annalisa; Costantino, Luca; Luciani, Rosaria; Tejera Nevado, Paloma; Zander-Dinse, Dorothea; Franco, Caio H.; Ferrari, Stefania; Moraes, Carolina B.; Cordeiro-da-Silva, Anabela; Ponterini, Glauco; Clos, Joachim; Alunda, Jose Maria; Costi, Maria Paola; European Journal of Medicinal Chemistry; vol. 183; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, Tetrolic acid (42 mg, 0.5 mmol) was dissolved in methanol (2 mL) followed by addition of 2-iodo-4,5-dimethoxyphenethylamine (154 mg, 0.5 mmol), benzothiophene-3-carbaldehyde (81 mg, 0.5 mmol) and tert-butyl isocianide (42 mg, 0.5 mmol). The reaction mixture was stirred at rt for 48 h in a sealed screw cap vial. The resulting mixture was concentrated and subjected to the column chromatography on silicagel with hepthane-EtOAc (15-25%) as eluent to give the desired propargylamide 7i?. Mixture of rotamers ?9:1.17 Yield: 142 mg, 46%. 1H NMR (300 MHz, CDCl3): delta 8.02 (s, 0.9H), 7.93-7.82 (m, 1H), 7.80-7.62 (m, 1.1H), 7.46-7.31 (m, 2H), 7.03 (s, 0.9H), 6.91 (s, 0.1H), 6.42 (s, 0.1H), 6.38 (s, 0.9H), 6.31 (s, 0.1H), 6.23 (s, 0.9H), 6.06 (br s, 0.9H), 5.65 (br s, 0.1H), 3.92-3.49 (m, 7.9H), 3.45-3.28 (m, 0.1H), 2.90-2.65 (m, 1H), 2.29-2.08 (m, 1.3H), 2.03 (s, 2.7H), 1.41 (s, 0.9H), 1.38 (s, 8.1H); 13C NMR (75 MHz, CDCl3, major rotamer): delta 168.0, 155.8, 149.3, 148.0, 139.6, 138.5, 134.2, 129.3, 128.1, 125.2, 125.0, 123.0, 121.6, 121.4, 112.7, 90.3, 87.3, 73.7, 56.1, 56.0, 54.6, 51.8, 46.9, 40.3, 28.6, 5.0; HRMS (EI, [M]+) for C28H31IN2O4S calcd 618.1049, found 618.1040.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Peshkov, Anatoly A.; Peshkov, Vsevolod A.; Pereshivko, Olga P.; Van Der Eycken, Erik V.; Tetrahedron; vol. 71; 23; (2015); p. 3863 – 3871;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.

95-15-8, General procedure: Benzo[b]thiophene was used as an arene, and 1,1,2,2-tetrabromoethane (Br2HCCHBr2) was used as an electrophilic reagent. The arene was reacted with Na-TMP in the same manner as in Experiment Number 2, the electrophilic reagent was added thereto and reacted therewith at -78 C. for 1 hour, the product was then evaluated, and the yield of isolated 2-bromo-benzo[b]thiophene in which a bromo group (-Br) was added at 2-position of benzo[b]thiophene was calculated. The isolated yield was 81%.

As the paragraph descriping shows that 95-15-8 is playing an increasingly important role.

Reference£º
Patent; KOBELCO ECO-SOLUTIONS CO.,LTD.; MURAKAMI, Yoshiaki; FUKUSHIMA, Miyuki; TAKAI, Kazuhiko; ASAKO, Sobi; (16 pag.)US2019/359571; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-03-0,Benzo[b]thiophen-3(2H)-one,as a common compound, the synthetic route is as follows.

PREPARATION 36 2-(2,2a,3,4-Tetrahydroindeno[7,1-bc]thiophen-4-yl)ethylamine The title compound is obtained by following the procedure of Preparation 35, starting from 2,3-dihydrobenzo[b]thiophen-3-one.

130-03-0, 130-03-0 Benzo[b]thiophen-3(2H)-one 10986413, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Les Laboratoires Servier; US6423870; (2002); B1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of pyrrole-2-carbaldehyde 1a,b (2 mmol) in MeOH (3 mL) were added successively Na2SO4 (0.3 g), the appropriate amine 2ad (1.2 equiv), acid 3a (1.2 equiv), and isonitrile 4a,b (1.2 equiv) in a screw capped vial equipped with a magnetic stir bar. The reaction mixture was stirred at 50 C for 2448 h in a closed vial. After completion of the reaction (as indicated on TLC), the mixture was diluted with EtOAc (100 mL) and extracted with H2O (50 mL). The organic layer was washed with brine (50 mL), dried (MgSO4) and evaporated under reduced pressure to obtain a residue, which was subjected to silica gel column chromatography (50% EtOAc in heptane) to afford the desired products 5ad (Table 1)., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kumar, Amit; Vachhani, Dipak D.; Modha, Sachin G.; Sharma, Sunil K.; Parmar, Virinder S.; Van Der Eycken, Erik V.; Synthesis; vol. 45; 18; (2013); p. 2571 – 2582;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, General procedure: The reaction was performed in a 20 mL V-type tube equipment with a triangle magnetic stirring bar. In a typical reaction, 4-hydroxyindole (0.4 mmol) was mixed with malonodinitrile (0.4 mmol) and aldehydes (0.4 mmol) in 2.0 mL of ethanol. KF (0.08 mmol) was then added. The mixture was subsequently heated to 60 C under stirring for 6 h. After the reaction, the mixture was cooled to room temperature, and the target product was isolated using a preparative thin-layer chromatograph (TLC) with eluting solution [petroleum ether/ethyl acetate 3/1 (v/v)].

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Bai, Rongxian; Yang, Jian; Min, Lijun; Liu, Changhui; Wu, Fengtian; Gu, Yanlong; Tetrahedron; vol. 72; 17; (2016); p. 2170 – 2177;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

In the glove box,Cs2CO3 (0.6 mmol) and benzothiophene-2-carbaldehyde (0.2 mmol) were weighed into a 25 mL reaction tube,Measure the amount of DMA (1 mL) into the reaction tube.A bromodifluoromethylphosphonium salt (0.6 mmol) was weighed,Treated with DMA (2 mL)Inhalation into the syringe.Stirred at room temperature,A DMA solution of bromodifluoromethylphosphonium salt was injected into the reaction tube at a rate of 0.5 mL / h with a syringe pump.After the injection, the reaction is over. The solution in the reaction tube was transferred to a separatory funnel, 15 mL of water was added, extracted three times with dichloromethane (10 mL x 3), and the organic phases were combined and washed three times with water (10 mL x 3). The final obtained organic phase was dried over anhydrous sodium sulfate, and the solid was filtered off, the solvent removed by rotary evaporation, on a silica gel column with n-pentane and ethyl acetate as eluent, to give the final isolated product difluoromethyl, yield 75%, purity> 99.9% (nuclear magnetic purity).

3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences; Xiao, Jichang; Deng, Zuyong; Lin, Jinhong; (37 pag.)CN106146556; (2016); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem