20532-33-6, 5-Chlorobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5-chloro-2-(4-hydroxy-1-(tert-butoxycarbonyl)piperidin-4-yl)benzothiophene A solution of 0.60 gm (3.56 mMol) 5-chlorobenzothiophene 1.55 mL in 20 mL freshly distilled tetrahydrofuran was cooled to -78C under a nitrogen atmosphere. To this was then added a solution of 2.94 mL (3.56 mMol) n-butyllithium and the reaction mixture was stirred at -78C for 1 hour. To the resulting anion solution was added dropwise a solution of 0.779 gm (3.91 mMol) 1- tert -butoxycarbonyl-4-piperidone and then the reaction mixture was allowed to warm to 0C. The reaction mixture was then quenched with saturated aqueous sodium bicarbonate, diluted with 1:1 hexanes:diethyl ether and the phases separated. The organic phase was washed with saturated aqueous sodium chloride, dried over sodium sulfate and concentrated under reduced pressure. The residue was subjected to flash silica chromatography, eluding with toluene containing 10% ethyl acetate. Fractions shown to contain product were combined and concentrated under reduced pressure to give 1.09 gm of the desired compound as a colorless foam contaminated with 20% 1- tert -butoxycarbonyl-4-piperidone. MS(FD): m/e=367 (M+), 20532-33-6
As the paragraph descriping shows that 20532-33-6 is playing an increasingly important role.
Reference£º
Patent; ELI LILLY AND COMPANY; EP812826; (1997); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem