With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154650-81-4,Benzo[b]thiophene-6-carbonitrile,as a common compound, the synthetic route is as follows.
A round bottom flask was charged with benzo[b]thiophene-6-carbonitrile (1.35 g, 8.48 mmol), methylene chloride (270 mL), and m-chloroperbenzoic acid (70% purity, 5.85 g, 23.73 mmol) was added in portions over 20 minutes. The reaction mixture was heated at 45 0C overnight. The reaction gave a mixture of sulfoxide and sulfones in 2: 1 ratio. The reaction was diluted with ethyl acetate and quenched with saturated aqueous sodium thiosulfate and stirred for 1 hour. The mixture was then extracted with ethyl acetate and the organic phase was concentrated under reduced pressure. The residue was purified by flash chromatography to afford the title compound as a white solid.
154650-81-4, The synthetic route of 154650-81-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; RENOVIS, INC.; WO2009/110985; (2009); A2;,
Benzothiophene – Wikipedia
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