5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
General procedure: Aldehyde 1a (1.0 equiv, 0.5 mmol, 91.1 mg), potassium salt 2 (PhSO2CF2CO2K) (1.5 equiv, 0.75 mmol, 205.7 mg) and anhydrous acetonitrile (5.0 mL) were added into a 10 mL sealed tube under a N2 atmosphere. The resulting mixture was stirred at 50 C for 7 h, and was then stirred at 80 C for 3 h. The solvent was removed by concentration under reduced pressure. The residue was subjected to flash column chromatography to afford the pure product 4a
The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Chen, Jia; Lin, Jin-Hong; Xiao, Ji-Chang; Tetrahedron; vol. 74; 32; (2018); p. 4295 – 4297;,
Benzothiophene – Wikipedia
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