Downstream synthetic route of 17402-83-4

The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

14.92 g of 4-aminobenzothiophene, 17.85 g of bis(2-chloroethyl)amine hydrochloride and 11.13 g of sodium carbonate were dissolved in 120 mL of n-butanol.The reaction was refluxed for 6 h, and cooled to give benzo[b]thiophen-4-ylpiperazine hydrochloride. The benzo[b]thiophen-4-ylpiperazine hydrochloride was dissolved in water, adjusted to pH 12 with 2 mol/L NaOH, and extracted with ethyl acetate.The ethyl acetate extract was washed successively with saturated sodium chloride solution and deionized water until neutral.Drying with anhydrous sodium sulfate, removing the solvent to obtain benzo[b]thiophen-4-ylpiperazine;, 17402-83-4

The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wuhan Xing Hua Knowledge Pharmaceutical Technology Co., Ltd.; Lu Shan; Chen Jingrun; Zhang Chuantao; (16 pag.)CN109988162; (2019); A;,
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New learning discoveries about 154650-81-4

154650-81-4, As the paragraph descriping shows that 154650-81-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154650-81-4,Benzo[b]thiophene-6-carbonitrile,as a common compound, the synthetic route is as follows.

To a stirred solution of benzo[b]thiophene-6-carbonitrile (1.0 g, 6.289 mmol) in CHC13 (7 mL) and acetic acid (7 mL) was added NBS (1.34 g, 7.547 mmol) portionwise at 0C and the mixture stirred at rt for 48 hr. The reaction mixture was diluted with DCM (60 mL) and washed with saturated solution of sodium thiosulfate solution and NaHCO3 followed by brine. The organic layer was dried over sodium sulfate, concentrated under reduced pressure to afford the crude material which was purified by column chromatography using silica gel (100-200 mesh) and 2% EtOAc/hexane as eluent to 3-bromobenzo[b]thiophene-6-carbonitrile (0.8 g, 3.359 mmol, 53%) as off white solid. GCMS: 238 (mlz).

154650-81-4, As the paragraph descriping shows that 154650-81-4 is playing an increasingly important role.

Reference£º
Patent; CURADEV PHARMA PRIVATE LTD.; BANERJEE, Monali; MIDDYA, Sandip; SHRIVASTAVA, Ritesh; RAINA, Sushil; SURYA, Arjun; YADAV, Dharmendra B.; YADAV, Veejendra K.; KAPOOR, Kamal Kishore; VENKATESAN, Aranapakam; SMITH, Roger A.; THOMPSON, Scott K.; WO2014/186035; (2014); A1;,
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Some tips on 3541-37-5

3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of benzo[b]thiophene-2-carbaldehyde (12 g, 0.074 mol) and hydroxylamine hydrochloride (15.32 g, 0.222 mol) in anhydrous methanol (250 mL) was added potassium carbonate (30.64 g, 0.222 mol) at room temperature. The mixture was stirred at room temperature for 4 hours. On completion, the mixture was filtered and purified by column chromatography [petroleum ether/ethyl acetate=20: l] to give compound B-102 (1 1.8 g, 90% yield) as a white solid. LCMS: (ES+) m/z (M+H)+ = 178.1 , tR=1.218., 3541-37-5

3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
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Some tips on 5381-25-9

As the paragraph descriping shows that 5381-25-9 is playing an increasingly important role.

5381-25-9, 1-Benzothiophene-3-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production example 10370 mg of oxalyl chloride was added to a mixture of 400 mg of benzo[b]thiophene-3-carboxylic acid and 20 ml of methanol under ice cooling. This mixture was stirred for 2 hours at 80C. After being cooled to room temperature, the reaction mixture was concentrated under reduced pressure. Tert-butyl methyl ether was added to the residues, and the residue was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated saline. The organic layer was dried over magnesium sulfate and then concentrated under reduced pressure, thereby obtaining 380 mg of methyl benzo[b]thiophene-3-carboxylate (hereinafter, described as a “compound 12 of the present invention”).1H-NMR (CDCl3) delta: 8.60 (m, 1H), 8.39 (s, 1H), 7.88 (m, 1H), 7.49 (m, 1H), 7.43 (m, 1H), 3.97 (s, 3H), 5381-25-9

As the paragraph descriping shows that 5381-25-9 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2923573; (2015); A1;,
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Brief introduction of 146137-92-0

146137-92-0 Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate 1477956, abenzothiophene compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146137-92-0,Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.,146137-92-0

Production Example 6; A mixture of 5.00 g of methyl 5- ( trifluoromethyl ) benzo [ b] thiophene-2-carboxylate, 2.93 g of potassium carbonate, 20 ml of water and 60 ml of methanol was stirred at 80C for 3 hours. The reaction mixture was cooled to room temperature, and then concentrated under reduced pressure. The residue was recrystallized from water to obtain 3.74 g of potassium 5- ( trifluoromethyl ) benzo[ b] thiophene-2-carboxylate (hereinafter referred to as “the present compound 6”) .[ The present compounds 6]1H-NMR ( DMSO-d6 ) delta: 8.20(s, 1H), 8.07(d, J=8.5Hz, 1H) , 7.61(s, 1H), 7.56(d, J=8.5Hz, 1H)

146137-92-0 Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate 1477956, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; MUKUMOTO, Fujio; TAMAKI, Hiroaki; IWAKOSHI, Mitsuhiko; KUSAKA, Shintaro; WO2012/153861; (2012); A1;,
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Simple exploration of 95-15-8

95-15-8 Thianaphthene 7221, abenzothiophene compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.

95-15-8, EXAMPLE 1 N-(1-trans-(2-(benzo[b]thien-2-yl)cyclopropyl)ethyl)-N-hydroxyurea STR18 To a solution of benzo[b]thiophene (11.49 g, 85.6 mmol) in 300 mls THF at -78 C., was added n-butyllithium (36.0 mls of a 2.5M solution in hexanes, 89.9 mmol) dropwise and the mixture was stirred for 30 mins at -78 C. N,N,-Dimethyl-formamide (6.57 g, 89.9 mmol) was added and the reaction was allowed to stir for 30 min. The cooling bath was then withdrawn and the reaction was allowed to warm to room temperature It was then diluted with saturated aqueous NH4 Cl (250 mL) and extracted with ethylacetate (3*250 mL). The organics were combined, dried with MgSO4 and concentrated. The resulting residue was taken up in 20 mL ethanol and saturated aqueous NaHSO3 (200 mL) was added. The resulting precipitate was collected and washed with ether. It was then dissolved in saturated aqueous Na2 CO3 (200 mL) and the resulting aqueous solution was extracted with ethylacetate (3* 200 mL). The organics were combined, dried with MgSO4 and concentrated to afford 13.63 g (98%) of benzo[b]thien-2-ylcarboxaldehyde.

95-15-8 Thianaphthene 7221, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Abbott Laboratories; US5120752; (1992); A;,
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Brief introduction of 154650-81-4

154650-81-4, The synthetic route of 154650-81-4 has been constantly updated, and we look forward to future research findings.

154650-81-4, Benzo[b]thiophene-6-carbonitrile is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a) 3-Bromo-1-benzothiophene-6-carbonitrile To a solution of 1-benzothiophene-6-carbonitrile (2.13 g, 13.4 mmol) in dry DMF (20 mL) at -10 C. was added freshly recrystallized N-bromosuccinimide (2.38 g, 13.4 mmol). The solution was allowed to warm to room temperature and stirred over the weekend. The mixture was diluted with water and extracted into diethyl ether, and the organic extract washed with water, then brine. The extracts were dried (MgSO4), filtered and evaporated in vacuo. The crude product was purified by flash chromatography on silica, eluding with ethyl acetate/hexane (1:9), to yield the title compound as a white solid.

154650-81-4, The synthetic route of 154650-81-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Agejas-Chicharro, Javier; Belen Bueno Melendo, Ana; Camp, Nicholas Paul; Gilmore, Jeremy; Jimenez-Aguado, Alma Maria; Lamas-Peteira, Carlos; Marcos-Llorente, Alicia; Mazanetz, Michael Philip; Montero Salgado, Carlos; Timms, Graham Henry; Williams, Andrew Caerwyn; US2004/122001; (2004); A1;,
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Simple exploration of 346592-74-3

346592-74-3, 346592-74-3 7-Fluorobenzo[b]thiophene 21866059, abenzothiophene compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.346592-74-3,7-Fluorobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

2-Fluorothiophenol (4.14 g, 32.6 mmol) was dissolved in anhydrous THF (100 mL). Potassium tert-butoxide (1.0 M in THF, 35.8 mL) was added and the suspension was stirred at room temperature for 15 minutes. 2-Chloroacetaldehyde dimethyl acetal was added and the mixture was stirred for 3 days. Water (100 mL) was added and the solution was extracted with diethyl ether (3¡Á100 mL). The extracts were concentrated to a yellow oil and chromatographed (5 to 20% ethyl acetate in hexane) to yield 1-(2,2-dimethoxy-ethylsulfanyl)-2-fluoro-benzene (6.42 g) as a colorless oil. Chlorobenzene (25 mL) was heated to reflux and polyphosphoric acid (1 mL) was added. The 1-(2,2-dimethoxy-ethylsulfanyl)-2-fluoro-benzene was then added slowly turning the solution dark. After 3 hours of heating, the reaction was cooled to room temperature and diluted with water (50 mL). The solution was extracted with benzene (2¡Á50 mL). The extracts were concentrated and chromatographed (0 to 15% ethyl acetate in hexane) to yield 7-fluorobenzothiophene (0.77 g). The 7-fluorobenzothiophene (0.77 g, 5.1 mmol) and dichloromethyl methyl ether (0.872 g, 7.6 mmol) were dissolved in anhydrous DCM (25 mL). Titanium tetrachloride (1.0 M in DCM, 7.6 mL, 7.6 mmol) was added, turning the solution dark. After 30 minutes at room temperature, the reaction was poured into a mixture of saturated aqueous NaHCO3 and ice. The mixture was stirred for about 30 minutes and then was extracted with DCM (2¡Á50 mL). The extracts were concentrated and chromatographed (0 to 15% ethyl acetate in hexane) to yield 7-fluorobenzothiophene-3-carboxaldehyde (0.642 g). The 7-fluorobenzothiophene-3-carboxaldehyde (0.642 g, 3.77 mmol) and sulfamide (1.7 g, 18 mmol) were combined in anhydrous ethanol (20 mL) and heated to reflux for three days. The reaction was cooled to room temperature and sodium borohydride (0.148 g, 3.92 mmol) was added. After two hours, water (25 ml) was added and the solution was extracted with chloroform (3¡Á25 mL). The extracts were concentrated, suspended in a minimal amount of DCM, and filtered to yield the title compound as a yellow solid.1H NMR (DMSO-d6): delta 7.78 (1H, d, J=8.0 Hz), 7.43-7.50 (1H, m), 7.27 (1H, dd, J=10.3, 7.9 Hz), 7.14 (1H, t, J=6.4 Hz), 6.74 (2H, br s), 4.31 (2H, d, J=6.4 Hz).

346592-74-3, 346592-74-3 7-Fluorobenzo[b]thiophene 21866059, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Smith-Swintosky, Virginia L.; US2007/191461; (2007); A1;,
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Brief introduction of 5381-20-4

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, General procedure: Benzo[b]thiophene-3-carbaldehyde (40 mg, 0.25 mmol, 1.0 equiv),Pd(TFA) 2 (4.2 mg, 5 mol%), (4-FC 6 H 4 ) 3 P (9.5 mg, 12 mol%), DPEphos (8mg, 6 mol%), and Cs 2 CO 3 (122 mg, 0.375 mmol) were placed in atransparent Schlenk tube equipped with a stirring bar. The tube wasevacuated and filled with argon for three times. Degassed DMF (2.5mL) and tert-butyl bromide (51 mg, 0.375 mmol, 1.5 equiv) were add-ed via a gastight syringe. The reaction mixture was stirred under theirradiation of 36 W blue LEDs (distance app. 2.0-3.0 cm from thebulb) at r.t. for 24 h. The mixture was quenched with brine and ex-tracted with EtOAc (3 ¡Á 10 mL). The organic layers were combinedand concentrated under reduced pressure. The product was purifiedby flash column chromatography on silica gel using PE or a mixture of PEand EtOAc (10:1 v/v) as eluent; yield: 50.1 mg (92%); pale yellow liquid.

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Guang-Zu; Shang, Rui; Fu, Yao; Synthesis; vol. 50; 15; (2018); p. 2908 – 2914;,
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Downstream synthetic route of 34761-09-6

34761-09-6, As the paragraph descriping shows that 34761-09-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34761-09-6,Ethyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 3-aminobenzo[b]thiophene-2-carboxylate 7 (0.9 mmol) in glacial acetic acid (5ml) water solution of NaNO2( 1.8 mmol) was added dropwise. The mixture was left under stirring for 2h at rt. Then ammonium acetate (32.4 mmol) and an appropriate primary amine 9a-e (10 mmol) were added. The precipitate was filtered off, and the crude was recrystallized from ethanol.

34761-09-6, As the paragraph descriping shows that 34761-09-6 is playing an increasingly important role.

Reference£º
Article; Lauria, Antonino; Alfio, Alessia; Bonsignore, Riccardo; Gentile, Carla; Martorana, Annamaria; Gennaro, Giuseppe; Barone, Giampaolo; Terenzi, Alessio; Almerico, Anna Maria; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3291 – 3297;,
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