5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5381-20-4, Compound 1 (200.0 mg, 0.46 mmol) and thianaphthene-3-carboxaldehyde(186.5 mg, 1.14 mmol) were dissolved in benzene (40 mL).Acetic acid (400 muL) and piperidine (400 muL) were added. The reactionmixture was refluxed using Dean-Stark apparatus until compound 1 wasconsumed. After the reaction was completed, it was extracted withCH2Cl2 and water. The organic layer was collected and dried with sodiumsulfate, evaporated under reduced pressure. The product waspurified by silica gel column chromatography using n-hexane-CH2Cl2(1:2) as mobile phase. Fractions containing compound 3 were collected,then the solvent was removed under reduced pressure (90.0 mg, 27%).MALDI TOF (m/z) Calc. 725.23, Found: 725.84 [M+]. 1H NMR(500 MHz, CDCl3) deltaH 8.09 (d, J=7.9 Hz, 2H, Ar-CH), 7.91 (d,J=7.9 Hz, 2H, Ar-CH), 7.88 (s, 2H, S-CH), 7.87 (d, J=16.2 Hz, 2H,trans-CH), 7.56 (d, J=16.2 Hz, 2H, trans-CH), 7.50 (t, J=7.4 Hz 2H,Ar-CH), 7.43 (t, J=7.4 Hz 2H, Ar-CH), 7.22 (d, J=8.2 Hz, 2H, Ar-CH), 7.03 (d, J=8.2 Hz, 2H, Ar-CH), 6.73 (s, 2H, Ar-CH), 4.07 (t,J=5.6 Hz 2H, OCH2), 3.41 (t, J=6.5 Hz, 2H, N3CH2), 1.9-1.8 (m, 4H,CH2CH2), 1.55 (s, 6H, Ar- CH3), ppm.13C NMR (126 MHz, CDCl3) deltaC159.5, 152.4,142.2, 140.5, 138.9, 137.4, 133.9, 133.7, 129.7, 127.3,127.2, 125.2, 124.8, 124.7, 122.9, 121.9, 120.3, 117.6, 114.9, 67.3,51.2, 26.5, 25.8, 14.9 ppm.
The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Tanr?verdi Ecik, Esra; ?enkuytu, Elif; Okutan, Elif; Yenilmez Ciftci, Goenuel; Inorganica Chimica Acta; vol. 495; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem