Downstream synthetic route of 351005-12-4

351005-12-4, As the paragraph descriping shows that 351005-12-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.351005-12-4,5-Bromo-1,3-dihydrobenzo[c]thiophene 2,2-dioxide,as a common compound, the synthetic route is as follows.

Under classical Heck reaction conditions, 5-Bromo-l,3-dihydro-benzo(c)thiophene 2,2 -dioxide was transformed with PPh3, Pd(OAc)2, TEA, and vinyltrimethylsilane at 90 C in DMF. The crude product was extracted with CH2Cl2 and concentrated. Deprotection in CH2C12/TFA gave the pure product after purification with flash chromatography (CH2Cl2) in high yields.

351005-12-4, As the paragraph descriping shows that 351005-12-4 is playing an increasingly important role.

Reference£º
Patent; VANDERBILT UNIVERSITY; WO2008/24435; (2008); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem