With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.
General procedure: To a solution of compound 6r (401.3 mg, 1 mmol), Pd(OAc)2 (22.5 mg, 0.1 mmol), P(O-Tolyl)3 (60.9 mg, 0.2 mmol), Et3N (303.6 mg, 417 muL, 3 mmol) in ACN (10 mL) was added a solution of R2X (heteroaryl or aryl halides, X=Br, I; 1.5 mmol) in ACN (5 mL) dropwise under an argon atmosphere in a sealed tube. The mixture was stirred under an argon atmosphere at 40 C for 16-48 h. The reaction mixture was then cooled, concentrated under vacuum and re-dissolved in CH2Cl2. After filtering, the filtrate was washed with saturated NaCl aqueous solution, dried with MgSO4 and concentrated under vacuum. The crude material was purified by column chromatography (PE/EA) on silica gel to afford compound 6ra-rt.This reaction showed high stereo- and regioselectivity.
4923-87-9, As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.
Reference£º
Article; Chen, Peng; Zhang, Dianwen; Li, Meng; Wu, Qiong; Lam, Yuko P.Y.; Guo, Yan; Chen, Chen; Bai, Nan; Malhotra, Shipra; Li, Wei; O’Connor, Peter B.; Fu, Hongzheng; European Journal of Medicinal Chemistry; vol. 183; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem