4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4923-87-9
To a stirred solution of compound A (500 mg, 2.35 mmol, 1 eq) in DMF (7 mL) in a sealed tube were added CuCN (273 mg, 3.05 mmol, 1.3 eq) and pyridine (0.25 mL) respectively. The resulting mixture was degassed with argon for 30 minutes and stirred for 10 h at 170 C. The reaction mixture was cooled to RT and quenched with a solution of ethylene diamine (0.25 mL) in water (6 mL) and the organic components were extracted with ethyl acetate (60 ml). The organic layer was concentrated in vacuo and the crude material was purified by flash chromatography (Combiflash) using 100-200 mesh silica gel eluting with 10% ethyl acetate/ hexane to obtain the compound B (200 mg, 54%) as off white solid. [0341] FontWeight=”Bold” FontSize=”10″ H NMR (400 MHz, OMSO-d6) delta 8.43 (s, 1 H), 8.26 (d, / = 8 Hz, 1 H), 7.99 (2, / (0350) = 8 Hz, 1 H), 7.73-7.71 (m, 1 H), 7.58 (d, / = 6 Hz, 1 H).
As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.
Reference£º
Patent; ASANA BIOSCIENCES, LLC; THOMPSON, Scott, K.; PRIESTLEY, Tony; KUNDU, Mrinalkanti; SAHA, Ashis; NATH, Suvadeep; (126 pag.)WO2018/64135; (2018); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem