95-15-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.
EXAMPLE 35 1-[3-Acetylthio-3-(benzo[b]thien-2-ylcarbonyl)-2-methylpropionyl]-L-proline To a solution of 2.68 g. (0.020 mole) of benzo[b]-thiophene in 40 ml. of ether cooled at -20 C. is added 0.020 moles of n-butyl lithium (2.54 N solution in hexane). The mixture is stirred at -20 C. for 15 minutes, then is allowed to warm to room temperature. Then 2.70 g. (0.020 mole) of N-methylformamilide is added and the mixture is stirred for 24 hours. The reaction is quenched with water and the mixture is treated with saturated sodium bisulfite solution. The bisulfite addition product is collected by filtration. The wet cake is slurried in water and decomposed by the addition of solid sodium carbonate. The mixture is filtered and the solid is washed with water and dried to give 1.75 g. of benzo[b]thiophene-2-carboxaldehyde.
The synthetic route of 95-15-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; American Cyanamid Company; US4299769; (1981); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem