154650-81-4, Benzo[b]thiophene-6-carbonitrile is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A flask containing anhydrous cerium (III) chloride (4.64 g, 18.8 mmol) was flushed with nitrogen several times and placed under high vacuum. The solid was heated with a heat gun for several minutes to remove any excess water. The flask was re-filled with nitrogen and allowed to cool. THF (80 mL) was added and the suspension was stirred at room temperature for 3 h. The suspension was cooled to -78 0C and methyllithium (3.0 M solution in Et2O, 6.28 mL, 18.8 mmol) was added. After stirring for 1 h, benzo[b]thiophene-6-carbonitrile (1.00 g, 6.28 mmol) was added. The mixture was stirred for 5 h at -78 0C, then allowed to slowly warm to room temperature over 16 h. The mixture was cooled back to -78 0C, then treated with cone. NH4OH (30 mL). After warming to room temperature, the mixture was diluted with H2O and extracted with CH2Cl2. The combined organics were dried over Na2SO4, filtered and concentrated. The residue was then dissolved in CH2Cl2 and extracted with 2 N HCl. The combined aqueous layers were basified with 5 N NaOH, and extracted with CH2Cl2. The
154650-81-4, 154650-81-4 Benzo[b]thiophene-6-carbonitrile 21816574, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; AMGEN INC.; WO2009/137404; (2009); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem