With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10133-22-9,5-(Bromomethyl)benzo[b]thiophene,as a common compound, the synthetic route is as follows.
10133-22-9, 5-(Bromomethyl)benzo[b]thiophene (312 mg, 1.37 mmol) and 7 thiourea (35 mg, 0.46 mmol) were dissolved in 8 ethanol (10 mL). The reaction mixture was refluxed for 2 hours. The reaction mixture was cooled, and ethanol was removed under reduced pressure. The resulting residue was suspended in dichloromethane. The suspension was filtered to give a product as a white solid (117 mg, 84%); 1H NMR (300 MHz) (DMSO-d6) delta 9.16 (bs, 2H), 8.94 (bs, 2H), 8.01 (d, J=8 Hz, 1H), 7.90 (s, 1H), 7.81 (d, J=5 Hz, 1H), 7.45 (d, J=6 Hz, 1H), 7.39 (d, J=8 Hz, 1H), 4.58 (s, 2H); LC/MS RT=2.50 (M+H+: 223).
10133-22-9 5-(Bromomethyl)benzo[b]thiophene 11160498, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; TAXIS PHARMACEUTICALS, INC.; LaVoie, Edmond J.; Parhi, Ajit K.; Sun, Yangsheng; (77 pag.)US2019/31624; (2019); A1;,
Benzothiophene – Wikipedia
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