With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.
General procedure: A mixture of 4-aminoacetophenone (0.01 mol) with 0.01 mol of NaOH dissolved in 50 mL of water and 50 mL of ethanole was stirred for 30 min. Upon addition of 5-phenylthiophene-2-carboxy aldehyde or benzo[b]thiophene-2-carboxy aldehyde (0.01 mol), the reaction mixture was stirred at room temperature for 8-10 h. The reaction progress was monitored by TLC. Upon completion of the process, the mixture was cooled down to room temperature. The separated crystalline solid was purified by crystallization from ethanol-water (2 : 1) and dried.
3541-37-5, The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Uenver; Tuluk; Kahriman; Emirik; Bekta?; Direkel; Russian Journal of General Chemistry; vol. 89; 4; (2019); p. 794 – 799;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem