With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1034305-11-7,Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol,as a common compound, the synthetic route is as follows.
Will 35.4g (105mmol)Benzo[b]thiophene-2-methanol, alpha-(5-bromo-2-fluorophenyl) (compound of formula 3) is solubleIn 800 mL of dichloromethane,And cooled to -20 C,To this solution was added 36.5 mL (230 mmol)Triethylsilane and 15.2 mL (120 mmol) of boron trifluoride etherate,The mixture was stirred at -20 C for 30 minutes.A saturated aqueous solution of sodium hydrogencarbonate was added to the reaction mixture.The organic phase was separated and dried over magnesium sulfate.It is then filtered and dried under vacuum.The obtained crude product was purified by column chromatography (ethyl acetate-hexane).Obtaining benzo[b]thiophene,2-[(5-Bromo-2-fluorophenyl)methyl](Compound 4) 30.4g;purity99.5%; yield 90.1%;
1034305-11-7, 1034305-11-7 Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol 59281673, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; Anqing Qichuang Pharmaceutical Co., Ltd.; Wu Xueping; Hai Wei; (13 pag.)CN108276396; (2018); A;,
Benzothiophene – Wikipedia
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