Day: September 21, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1034305-11-7,Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol,as a common compound, the synthetic route is as follows.

Will 35.4g (105mmol)Benzo[b]thiophene-2-methanol, alpha-(5-bromo-2-fluorophenyl) (compound of formula 3) is solubleIn 800 mL of dichloromethane,And cooled to -20 C,To this solution was added 36.5 mL (230 mmol)Triethylsilane and 15.2 mL (120 mmol) of boron trifluoride etherate,The mixture was stirred at -20 C for 30 minutes.A saturated aqueous solution of sodium hydrogencarbonate was added to the reaction mixture.The organic phase was separated and dried over magnesium sulfate.It is then filtered and dried under vacuum.The obtained crude product was purified by column chromatography (ethyl acetate-hexane).Obtaining benzo[b]thiophene,2-[(5-Bromo-2-fluorophenyl)methyl](Compound 4) 30.4g;purity99.5%; yield 90.1%;

1034305-11-7, 1034305-11-7 Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol 59281673, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Anqing Qichuang Pharmaceutical Co., Ltd.; Wu Xueping; Hai Wei; (13 pag.)CN108276396; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 4-aminoacetophenone (0.01 mol) with 0.01 mol of NaOH dissolved in 50 mL of water and 50 mL of ethanole was stirred for 30 min. Upon addition of 5-phenylthiophene-2-carboxy aldehyde or benzo[b]thiophene-2-carboxy aldehyde (0.01 mol), the reaction mixture was stirred at room temperature for 8-10 h. The reaction progress was monitored by TLC. Upon completion of the process, the mixture was cooled down to room temperature. The separated crystalline solid was purified by crystallization from ethanol-water (2 : 1) and dried.

3541-37-5, The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Uenver; Tuluk; Kahriman; Emirik; Bekta?; Direkel; Russian Journal of General Chemistry; vol. 89; 4; (2019); p. 794 – 799;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

22913-24-2, Methyl benzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 60% NaH (0.12g, 5mmol) was added in anhydrous THF (10mL), followed by the addition of anhydrous CH3CN (0.21g, 5mmol) and compound 2 (0.42g, 2.5mmol) in the ice bath. Reaction was heated to reflux and stirred for 6h. Upon completion, the reaction mixture was taken up in ice water (30mL) and the pH was adjusted to 5. After filtration, the filtrate was extracted with ethyl acetate (20mL¡Á3). The combined organic phase was washed twice with saturated brine (20mL¡Á2) and dried over anhydrous MgSO4. Then, MgSO4 was filtered out, and the filtrate was concentrated in vacuo, Followed by recrystallization of the residue to afford compound 19a as a pale-yellow solid.

22913-24-2, As the paragraph descriping shows that 22913-24-2 is playing an increasingly important role.

Reference£º
Article; Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 248 – 267;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Aminobenzo [b] thiophene 14. 92 g(100 mmol) was added to the reaction flask with di (2-chloroethyl) amine hydrochloride and 85 g (5 mmol) of p-toluenesulfonamide and 225 mL of xylene were added at 120 to 150 ¡ã C C under stirring for 16 hours. And then naturally dropped to room temperature, and then reduced to 0 ¡ã C for 2 hours, filtered to obtain white solid crystal 21. 66g, the yield of 85. 0percent, 98percent purity.

17402-83-4, The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shenzhen Foncoo Pharmaceutical Co., Ltd.,; Peng, Jin An; Zhou, Gewen; (6 pag.)CN105461703; (2016); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6314-28-9

Benzo[b]thiophene-2-carboxylic acid 2-[(benzo[b]thiophene-2-carbonyl)-(R)-amino]-3-[4-(3-hydroxycarbamoyl-propyl)-piperidin-1-yl]-3-oxo-propyl ester; A mixture of HOAt (20 mg, 0.15 mmols), Fmoc-D-Ser-OH (49 mg, 0.15 mmols) and diisopropylcarbodiimide (0.024 ml, 18 mg, 0.15 mmols) in 3 ml of DMF/DCM, previously maintained at ambient temperature for an hour, is added to the resin obtained in Step C, re-swollen in 2 ml of DCM for 20 minutes. The suspension is agitated for 18 hours at ambient temperature then the resin is filtered off and washed sequentially with DMF (2¡Á2 ml) and DCM (2¡Á2 ml).The resin is filtered off and suspended in 2 ml of a solution of 20% piperidine in dichloromethane. After 30 minutes the resin is filtered off and washed sequentially with DMF (2¡Á2 ml) and DCM (2¡Á2 ml).To the resin obtained in Step E and re-swollen in 2 ml of DCM for 20 minutes are added the mixture of HOAt (68 mg, 0.5 mmols), benzo[b]thiophene-2-carboxylic acid (90 mg, 0.5 mmols) and 0.08 ml of diisopropylcarbodiimide (63 mg, 0.5 mmols) in 3 ml of DMF/DCM previously held at ambient temperature for 1 hour. The suspension is agitated for 18 hours at ambient temperature. The resin is filtered off and washed sequentially with DMF (2¡Á2 ml) and DCM (2¡Á2 ml).100 mul of trifluoroacetic acid and 100 mul of triethylsilane are added to the thus obtained resin, re-swollen in 2 ml DCM for 20 minutes. It is maintained under agitation for 15 minutes at ambient temperature. The resin is filtered off and washed twice with DCM and MeOH alternately. The filtrates are pooled and evaporated to dryness. Grinding the crude product thus obtained with ethyl ether provides the desired product (41 mg, 75% yield) with a purity of 95% (HPLC, 214 nm). MF: C30H31N3O6S2, MW: 593.73.

The synthetic route of 6314-28-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Rossi, Cristina; Porcelloni, Marina; D’Andrea, Piero; Fattori, Daniela; Marastoni, Elena; US2008/207694; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6314-28-9, General procedure: At low temperature conditions,The thionyl chloride was slowly added to the solution of compound 4 in anhydrous dichloromethane,After dripping,The reaction was returned to room temperature and refluxed under nitrogen.After the reaction is complete,Steaming all solvents,Then dissolved in anhydrous tetrahydrofuran or anhydrous dichloromethane,Compounds 3 and pyridine were added at low temperature,The reaction was transferred to room temperature and overnight.To the reaction system by adding water,And extracted three times with ethyl acetate,Combine organic phase,Washed three times with saturated sodium bicarbonate solution and saturated brine,Dried over anhydrous sodium sulfate and subjected to column chromatography to give compound 6.

6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Jiao Tong University, School of Medicine; ZHANG, JIAN; CHENG, JIN KE; LIU, SHAO YONG; CHEN, TAN YI; ZHANG, JING MIAO; HUANG, MIN; (27 pag.)CN103961348; (2016); B;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of the appropriate aldehyde or ketone (1 eq.) in 50% aqueous ethanol (v/v), thiosemicarbazide (1 eq.) was added. The mixture was stirred at 60C for 2-12h, cooled at room temperature and diluted with water. The precipitate formed was collected and recrystallized from water and ethanol to give the desired product in 65-95% yield., 5381-20-4

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Linciano, Pasquale; Moraes, Carolina B.; Alcantara, Laura M.; Franco, Caio H.; Pascoalino, Bruno; Freitas-Junior, Lucio H.; Macedo, Sara; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Gul, Sheraz; Witt, Gesa; Kuzikov, Maria; Ellinger, Bernhard; Ferrari, Stefania; Luciani, Rosaria; Quotadamo, Antonio; Costantino, Luca; Costi, Maria Paola; European Journal of Medicinal Chemistry; vol. 146; (2018); p. 423 – 434;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6314-28-9, Benzo[b]thiophene-2-carboxylic acid (50 mg, 0.28 mmol)dichloromethane (3 mL) It was dissolved in thionyl chloride (SOCl2, 0.50 mL)and dimethylformamide (2 drops) It was added thereto, and was stirred for 20 minutes at 50C . Thereafter, the reaction mixture was concentrated under reduced pressure, dichloromethane (3 mL)after the diluted, quinolin-3-amine (50.0 mg, 0.347 mmol)and triethyl amine was added and stirred for a (100 mg, 0.988 mmol) and 15 hours at room temperature. Thin film chromatography (TLC) in verifying, new the spot location changes accordingly once created, reaction mixture of decompressing concentrated within, fraction is concentrated tosilica gel thin chromatography (preparative TLC, n/ethyl acetate = 2/1-hexanediol) for purifying the white solid thereby, a desired compound (23.0 mg, 27%) is obtained.

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

Reference£º
Patent; Korea research Institute of Chemical Technology; Han, Soo Bong; Achari, Ragavendra; Kim, Mi Hyeon; Jong, Yong Sik; Kim, Pil Ho; (119 pag.)KR2016/21163; (2016); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

89673-36-9, tert-Butyl benzo[b]thiophen-2-ylcarbamate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,89673-36-9

Benzo[Z>]thiophen-2-ylamine hydrochloride (1-C).; Compound 1-B (1.45 g, 5.81 mmol) was added to a solution of HCl in dioxane (4 N, 20 mL), and the mixture was stirred at rt until all the starting material was consumed. The mixture was diluted with diethyl ether, the product collected by filtration, and washed with diethyl ether, to afford compound 1-C as an off-white solid (0.89 g, 83%). 1H-NMR (DMSO-fe): delta 6.43 (s, IH), 6.8-7.2 (br s, 3H) superimposed on 7.05 (m, IH) and 7.20 (m, IH), 7.45 (d, IH), 7.66 (d, IH); MS: m/z 150.1 (MH+).

89673-36-9 tert-Butyl benzo[b]thiophen-2-ylcarbamate 13182766, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2009/12430; (2009); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20532-33-6,5-Chlorobenzothiophene,as a common compound, the synthetic route is as follows.

Example 11 A solution of 2-bromobutyryl chloride (8 g) in dichloromethane (15 ml) was added dropwise under nitrogen at ambient temperature to a stirred suspension of anhydrous aluminium chloride (12 g) in dichloromethane (100 ml). When the addition was complete, a solution of 5-chlorobenzo[b]thiophene (5 g; prepared in a manner similar to that described in J. Heterocyclic Chem., 1988, 25, 1271) in dichloromethane (30 ml) was added dropwise, then the mixture was stirred at ambient temperature for 1 hour and added to ice-cold water (500 ml). The mixture was stirred at ambient temperature for 30 minutes then the product was extracted into dichloromethane (100 ml). The extract was washed with water (2*30 ml) and saturated aqueous sodium chloride solution (2*30 ml), then it was dried (Na2SO4) and the solvent was removed in vacuo. The residue was purified by repeated (5-fold) flash chromatography over silica using a 19:1 mixture of petroleum ether (b.p. 60-80 C.) and ethyl acetate as eluant. Appropriate fractions were combined and the solvents removed in vacuo to give 2-bromo-1-(5-chlorobenzo[b]thiophen-2-yl)butan-1-one (1.04 g) as an off-white solid which was used without further purification.

20532-33-6, The synthetic route of 20532-33-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Doyle, Kevin James; Kerrigan, Frank; Watts, John Paul; US2003/166628; (2003); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem