With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24434-84-2,Benzo[b]thiophene-3-carbonitrile,as a common compound, the synthetic route is as follows.
(a) Methyl(benzo[b]thiophen-3-yl)imidate hydrochloride Benzo[b]thiophen-3-carbonitrile (700 mg) was dissolved in dry methanol (25 ml), and the resulting solution cooled to 10 C. under a dry nitrogen atmosphere. Dry hydrogen chloride gas was passed through the chilled solution for 40 minutes, and the resulting red solution allowed to stand at room temperature overnight. Removal of solvent under reduced pressure and recrystallisation from methanol/ether afforded the title compound as white needles (810 mg), m.p. 197-200 C. deltaH (360 MHz, DMSO-d6) 4.35 (3H, s, OCH3), 7.53 (2H, m, H-5,6), 8.19 (2H, m, H-4, 7) 8.41 (1H, s, H-2); m/z 191(M+, 70%) 160(100), 133(30), 89(40).
24434-84-2, The synthetic route of 24434-84-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Merck Sharp & Dohme Limited; US4940703; (1990); A;,
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