5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5381-20-4, Thianaphthene-3-carboxaldehyde (1.62 g, 10.0 mmol) was dissolved in anhydrous ethanol (50 ml_). Sulfamide (4.0 g, 42 mmol) was added and the mixture was heated to reflux for 16 hours. The mixture was cooled to room temperature. Sodium borohydride (0.416 g, 11.0 mmol) was added and the mixture was stirred at room temperature for three hours. The reaction was diluted with water (50 ml) and extracted with chloroform (3 x 75 ml_). The extracts were concentrated and chromatographed (5% methanol in DCM) and the solvent evaporate to yield the title compound as a white solid. 1H NMR (DMSO-(J6): delta 7.98 (1 H, dd, J = 6.5, 2.3 Hz), 7.92 (1 H, dd, J =6.6, 2.4 Hz), 7.62 (1 H, s), 7.36-7.45 (2H, m), 7.08 (1 H, t, J = 6.3 Hz), 6.72 (2H, S)1 4.31 (2H, d, J = 6.3 Hz).
5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/98486; (2007); A1;,
Benzothiophene – Wikipedia
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