With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34761-09-6,Ethyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
Synthesis 1B3H-[1]benzothieno[3,2-d]pyrimid-4-oneA stirred mixture of ethyl 3-aminobenzo[b]thiophene-2-carboxylate (3.62 mmol) in formamide (5 mL) was heated to 150C. Formamidine acetate (3.62 mmol) was added and the mixture heated at 150C for 45 min. The addition of formamidine acetate (3.62 mmol) was repeated every 45 min for 6 h. Ice-water was added and the precipitate that was formed was filtered off, washed with water, and dried in a vacuum oven to obtain the pyrimidine as a tanned solid (95%).LCMS rt 5.20; M+H 203; 1H-NMR (DMSO) delta D8.33 (1H, s), 8.26-8.21 (1H, m), 8.16-8.12 (1H, m), 7.69-7.56 (1H, m).
34761-09-6, The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BAELL, Jonathan Bayldon; STREET, Ian Philip; SLEEBS, Brad Edmund; WO2012/131297; (2012); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem