With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33851-23-9,Methyl 7-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
General procedure: A solution of potassium tert-butoxide (1.12 g, 10 mmol) in DMSO (10 mL) was stirred at room temperature. After 10 min, the respective methyl ester (1 mmol) was added and the reaction mixture was stirred at room temperature. Upon completion (TLC analysis), ice water (40 mL) was added and the mixture was acidified with 1 N HCl until pH 1. The precipitate was collected and washed with water (5 mL), cold diethyl ether (2 mL) and hexane (5 mL) and recrystallized from an appropriate solvent., 33851-23-9
33851-23-9 Methyl 7-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate 68543686, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Article; Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef; Bioorganic and Medicinal Chemistry Letters; vol. 22; 15; (2012); p. 5031 – 5034;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem