With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.
1423-61-6, Step a) preparation of 1-(t-butoxycarboyl)-4-(7-benzo(b)thiophene)-4-hydroxypiperidine:45 g of 7-bromobenzothiophene are dissolved in 135 ml of THF and the solution thus obtained is added dropwise to a suspension of 5.13 g of magnesium in 10 ml of THF in a round-bottomed flask under nitrogen. A catalytic amount of iodine is added and the mixture is heated at the reflux temperature for 3 hours. The resulting mixture is cooled to room temperature and a solution of 36 g of 1-(t-butoxycarbonyl)-4-piperidone in 80 ml of THF is added. This mixture is stirred for 3 hours at room temperature, and saturated ammonium chloride solution is added.The resulting mixture is extracted with ethyl acetate. The extracts are dried and evaporated under vacuum; the crude product thus obtained is purified by flash chromatography using 95/5 hexane/ethyl acetate as eluent. 47.5 g of a white solid with a melting point of 130-131 C. are isolated.
1423-61-6 7-Bromobenzo[b]thiophene 12045538, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; SANOFI; US2012/245150; (2012); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem