Day: September 17, 2020

16587-47-6, 6-Methylbenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(i) 2,3-Dibromo-6-methylbenzo[b]thiophene Bromine (15.2 g.) was added dropwise over 5 minutes to a stirred solution of 6-methylbenzo[b]-thiophene (7.0 g.) in chloroform (70 ml.) at room temperature. The resulting solution was stirred at room temperature for 4 hours and then evaporated. The residue was crystallized from methanol to give 2,3-dibromo-6-methylbenzo[b]thiophene (12.4 g.), m.p. 67.5-68.5 C. Analysis %: Found: C, 35.09; H, 1.90. C9 H9 Br2 S Requires: C, 35.33; H, 1.98%., 16587-47-6

The synthetic route of 16587-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc.; US4410539; (1983); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, This is based on Journal of Heterocyclic Chemistry, 18(5), 967-72, 1981. NaH (1.3 g, 28 mmol) was added to a mixture of 3-carbaldehydebenzo[b]thiophene (4.27 g, 25 mmol), diethyl benzylphosphonate (5.76 g, 25 mmol) in 50 mL of 1,2-dimethoxyethane at 0 C. under N2 and stirred for 15 minutes at 0 C. and 3 h at room temperature. The reaction mixture was then poured into ice water and filtrated. The solid from the filtration was recrystallized from ethanol to yield 4.5 g of desired product was obtained as a yellow solid. Synthesis of benzo[b]naphtha[2,1-d]thiophene.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Universal Display Corporation; US2011/266526; (2011); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00348] To a stirred solution of benzo[b]thiophen-4-amine (1 g, 6.70 mmol) and pyridine (1.355 mL, 16.75 mmol) in (?(? (15 mL) was added dropwise methanesulfonyl chloride (0.574 mL, 7.37 mmol) at 0 ¡ãC under nitrogen atmosphere. The reaction mixture was then allowed to warm to room temperature while stirring overnight. The reaction mixture was washed with saturated sodium bicarbonate solution, water, brine and dried over sodium sulfate. Evaporation of the solvent furnished a crude residue, which was subjected to BIOTAGE? (100percent methylene chloride) to give the title compound as a white solid (1.2g, 79percent). LC/MS: Example 105A (at) 2.88 min (RT) (Condition H). MS (ES): m/z=226.0, [M+H]+. XH NMR (400 MHz, MeOD) delta ppm 7.77 (1 hr, d, J=7.81 Hz), 7.59 (2 hr, d, J=1.26 Hz), 7.25-7.42 (2 hr, m), 2.94 (3 hr, s).

17402-83-4, As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; HUANG, Audris; VELAPARTHI, Upender; LIU, Peiying; WO2013/49263; (2013); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, Thianaphthene-3-carboxaldehyde (1.62 g, 10.0 mmol) was dissolved in anhydrous ethanol (50 ml_). Sulfamide (4.0 g, 42 mmol) was added and the mixture was heated to reflux for 16 hours. The mixture was cooled to room temperature. Sodium borohydride (0.416 g, 11.0 mmol) was added and the mixture was stirred at room temperature for three hours. The reaction was diluted with water (50 ml) and extracted with chloroform (3 x 75 ml_). The extracts were concentrated and chromatographed (5% methanol in DCM) and the solvent evaporate to yield the title compound as a white solid. 1H NMR (DMSO-(J6): delta 7.98 (1 H, dd, J = 6.5, 2.3 Hz), 7.92 (1 H, dd, J =6.6, 2.4 Hz), 7.62 (1 H, s), 7.36-7.45 (2H, m), 7.08 (1 H, t, J = 6.3 Hz), 6.72 (2H, S)1 4.31 (2H, d, J = 6.3 Hz).

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/98486; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34761-09-6,Ethyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 3-aminobenzo[b]thiophene-2-carboxylate 7 (0.9 mmol) in glacial acetic acid (5ml) water solution of NaNO2( 1.8 mmol) was added dropwise. The mixture was left under stirring for 2h at rt. Then ammonium acetate (32.4 mmol) and an appropriate primary amine 9a-e (10 mmol) were added. The precipitate was filtered off, and the crude was recrystallized from ethanol., 34761-09-6

34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Lauria, Antonino; Alfio, Alessia; Bonsignore, Riccardo; Gentile, Carla; Martorana, Annamaria; Gennaro, Giuseppe; Barone, Giampaolo; Terenzi, Alessio; Almerico, Anna Maria; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3291 – 3297;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Using a previously described method,23 a catalytic amount of anhydrous ZnI2 (3.2 mg, 20 mumol) and trimethylsilyl cyanide (119 mg, 1.2 mmol) was added to a stirred solution of one of the aldehydes 1a-d (1 mmol) in dry dichloromethane (10 mL) and the resulting mixture was stirred at room temperature until all of the aldehydes was transformed. The solvent was evaporated and the crude product was redissolved in 10 mL of methanol. The formed trimethylsilyl cyanohydrin decomposed when HCl (3 M, 5 mL) was added. The reaction mass was evaporated to the final volume of 5 mL, after which water (5 mL) and dichloromethane (10 mL) were added. After the separation of the two layers, the aqueous layer was extracted with dichloromethane (2 ¡Á 10 mL). The combined organic layers were dried over anhydrous Na2SO4 and the solvent was evaporated in vacuo.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Naghi, Mara Ana; Bencze, Laszlo Csaba; Brem, Juergen; Paizs, Csaba; Irimie, Florin Dan; Toa, Monica Ioana; Tetrahedron Asymmetry; vol. 23; 2; (2012); p. 181 – 187;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 122 N-(benzo[b]thiophen-4-yl)-6-methylthiazolo[3,2-b][1,2,4]triazole-2-sulphonamide The product of Example 1 stage (c) (1.1 g) was added portionwise with stirring to 4-aminobenzo(b)thiophene (0.7 g) in dimethylaniline (4 ml.). The mixture was allowed to stand for 3 days prior to treatment with dilute hydrochloric acid and ether. The precipitated solid was isolated by filtration, washed with dilute hydrochloric acid, water and ether, and dried to give 1.4 g of crude product. This solid was treated with dilute ammonia solution, filtered, and the filtrate acidified. The precipitated product was filtered off, washed with water and ether, and dried to give 0.8 g of desired product, mp 205¡ã-209¡ã C., 17402-83-4

The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schering Agrochemicals; US4795483; (1989); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34761-09-6,Ethyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

Synthesis 1B3H-[1]benzothieno[3,2-d]pyrimid-4-oneA stirred mixture of ethyl 3-aminobenzo[b]thiophene-2-carboxylate (3.62 mmol) in formamide (5 mL) was heated to 150C. Formamidine acetate (3.62 mmol) was added and the mixture heated at 150C for 45 min. The addition of formamidine acetate (3.62 mmol) was repeated every 45 min for 6 h. Ice-water was added and the precipitate that was formed was filtered off, washed with water, and dried in a vacuum oven to obtain the pyrimidine as a tanned solid (95%).LCMS rt 5.20; M+H 203; 1H-NMR (DMSO) delta D8.33 (1H, s), 8.26-8.21 (1H, m), 8.16-8.12 (1H, m), 7.69-7.56 (1H, m).

34761-09-6, The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAELL, Jonathan Bayldon; STREET, Ian Philip; SLEEBS, Brad Edmund; WO2012/131297; (2012); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

1423-61-6, Step a) preparation of 1-(t-butoxycarboyl)-4-(7-benzo(b)thiophene)-4-hydroxypiperidine:45 g of 7-bromobenzothiophene are dissolved in 135 ml of THF and the solution thus obtained is added dropwise to a suspension of 5.13 g of magnesium in 10 ml of THF in a round-bottomed flask under nitrogen. A catalytic amount of iodine is added and the mixture is heated at the reflux temperature for 3 hours. The resulting mixture is cooled to room temperature and a solution of 36 g of 1-(t-butoxycarbonyl)-4-piperidone in 80 ml of THF is added. This mixture is stirred for 3 hours at room temperature, and saturated ammonium chloride solution is added.The resulting mixture is extracted with ethyl acetate. The extracts are dried and evaporated under vacuum; the crude product thus obtained is purified by flash chromatography using 95/5 hexane/ethyl acetate as eluent. 47.5 g of a white solid with a melting point of 130-131 C. are isolated.

1423-61-6 7-Bromobenzo[b]thiophene 12045538, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; SANOFI; US2012/245150; (2012); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33851-23-9,Methyl 7-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: A solution of potassium tert-butoxide (1.12 g, 10 mmol) in DMSO (10 mL) was stirred at room temperature. After 10 min, the respective methyl ester (1 mmol) was added and the reaction mixture was stirred at room temperature. Upon completion (TLC analysis), ice water (40 mL) was added and the mixture was acidified with 1 N HCl until pH 1. The precipitate was collected and washed with water (5 mL), cold diethyl ether (2 mL) and hexane (5 mL) and recrystallized from an appropriate solvent., 33851-23-9

33851-23-9 Methyl 7-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate 68543686, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef; Bioorganic and Medicinal Chemistry Letters; vol. 22; 15; (2012); p. 5031 – 5034;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem