Simple exploration of 6314-28-9

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of phenylmethyl 4-L-leucyl-1-piperazinecarboxylate (1.0 g, 3.34 mmol) in CH2CI2 (13.5 ml_) was added EDC (571 mg, 2.98 mmol), HOOBt (8.8 mg, 0.054 mmol), i -benzothiophene-2-carboxylic acid (530mg, 2.98 mmol), and 4-methylmorpholine (1.5ml_, 13.5mmol). The reaction mixture was stirred at room temperature for 20 h whereupon the reaction was diluted with CH2CI2 and washed with 10% citric acid and brine. The organic layer was dried over Na2SO4, filtered, and concentrated. Column chromatography (10-80% ethyl acetate:hexane) afforded 1.3 g (88% yield) of the title compound as a white solid: LCMS (m/z): 494.2 (M+H)., 6314-28-9

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/70865; (2007); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Analyzing the synthesis route of 20699-85-8

The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of above Benzothiophene amine (104 mg, 0.5 mmol) in 5 mL of anhydrous DCM was added phenylacetic acid chloride (0.13 mL, 1.0 mmol) and DIEA (di-isopropyl ethylamine, 0.18 mL, 2.0 mmol) at room temperature under N2. The resulting mixture was stirred overnight. After work-up, the residue was purified on column (Hexanes:DCM : EtOAc = 3:1 :1 ) to afford compound 5-Phenylacetylamino- benzo[b]thiophene-2-carboxylic acid methyl ester. Yield: 71 %. LCMS m/z: 326 ([M+H]+)., 20699-85-8

The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; S*BIO PTE LTD; WO2006/101454; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Analyzing the synthesis route of 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of Mg turnings (15mmol) and iodine (two pieces) in dry diethyl ether (10mL) at room temperature equipped with a reflux condenser was added dropwise a mixture of allylbromide (11mmol) in anhydrous diethyl ether (5mL). The mixture was allowed to reflux for 30min. Then, the mixture was cooled down to 0C followed by dropwise addition of the corresponding aldehyde (benzofuran or benzothiophene) (10mmol) in dry diethylether (3mL). The resultant mixture was then stirred for 3h. The reaction mixture was hydrolyzed with saturated ammonium chloride solution (10mL) and then with 1M HCl (2mL). The resultant mixture was then extracted with diethyl ether (3¡Á30mL). The combined organic phase was washed with brine (20mL) and dried over MgSO4 and evaporated in vacuo. The crude products were purified by flash column chromatography with ethyl acetate/hexane mixture (1:5)., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bueyuekadal?, Nalan Nuriye; Aslan, Nezir; Guemue?, Selcuk; Guemue?, Ay?eguel; Tetrahedron Asymmetry; vol. 27; 19; (2016); p. 954 – 959;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Some tips on 4923-87-9

4923-87-9, The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.

5-bromobenzo[b]thiophene (3.0 g, 14.08 mmol) and 4-hydroxyphenylboronic acid (2.91 g, 21.11 mmol) were dissolved in DME 40 mL. Water 10 mL was added thereto. Pd(dbpf)Cl2 (459 mg, 0.70 mmol) and Cs2CO3 (13.68 g, 42.24 mmol) were added thereto, and refluxed with heating at 90 C for a day. The reaction mixture was filtered through Celite. The obtained filtrate was extracted with EtOAc three times, dried over MgSO4, and then concentrated under reduced pressure. The obtained concentrate was purified by silica gel column chromatography (15-20 % EtOAc/hexane) to yield the title compound as white solid (2.30 g, 72%).

4923-87-9, The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, ChangSik; JANG, TaegSu; CHOI, DaeKyu; KO, MoonSung; KIM, DoHoon; KIM, SoYoung; MIN, JaeKi; KIM, WooSik; LIM, YoungTae; WO2013/187646; (2013); A1;,
Benzothiophene – Wikipedia
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Some tips on 3541-37-5

3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of benzo [b] thiophene-2-carbaldehyde (1.0 g, 6.17 mmol) and carbon tetrabromide (3.1 g, 9.25 mmol) in methylene chloride (50 mL) was cooled to 0C. A solution of triphenylphosphine (4.86 g, 18.3 mmol) in methylene chloride (20 mL) was added dropwise. After 1/2 hour the solution was placed on a plug of silica gel and eluted with 20% ethyl acetate: hexane. Concentration of the eluent resulted in the isolation of 1.3 g (67%) of 2-(2, 2-Dibromo-vinvl)-benzorb1thiophene as a yellow oil, which was used as such in the next step

3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; WYETH; WO2005/37207; (2005); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Simple exploration of 6314-28-9

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: The heteroaryl acyl chlorides used in the synthesis of compounds 1b, 2b, 3b, 4b and 5b were commercially available. For compounds 6b, 7b, 8b, 9b and 10b, the chloride derivatives were prepared from the corresponding carboxylic acid (9.18 mmol) nd thionyl chloride (30 mL) with heating under reflux for 2 h. The thionyl chloride was removed in vacuo. The resulting acyl chloride was used without further purification., 6314-28-9

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

Reference£º
Article; Font, Maria; Lizarraga, Elena; Ibanez, Elena; Plano, Daniel; Sanmarti?, Carmen; Palop, Juan A.; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 489 – 498;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

New learning discoveries about 3541-37-5

3541-37-5, As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of appropriate piperazine base (i-vi, 1 mmol), aldehydes (1a-1d, 1 mmol) and around 1.1-1.3 mmol quantity of TMSCN was taken in 5-8 mL water. After stirring for a while, 10 mg Indium powder was added to the reaction mixture and the resulted reaction mass was allowed to stir at room temperature for 45 min-2.5 h. After the completion ofthe reaction as monitored by Thin Layer Chro-matography using toluene: acetone (8:2) or ethyl acetate: n-nexane (8:2) solvent system, after treatment with diethyl ether or ethyl acetate, solution was filtered and washed with water and brine followed by anhydrous sodium sulphate treatment to dry. The residue was purified by silica gel column chromatography (ethyl acetate: n-hexane) to afford compounds 2i-5vi.

3541-37-5, As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Patel, Rahul V.; Patel, Jigar K.; Nile, Shivraj H.; Park, Se Won; Letters in drug design and discovery; vol. 10; 5; (2013); p. 462 – 470;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

New learning discoveries about 130-03-0

The synthetic route of 130-03-0 has been constantly updated, and we look forward to future research findings.

130-03-0, Benzo[b]thiophen-3(2H)-one is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 5 mL flame-dried microwave flask was added benzo[b]thiophen-3(2H)-one (0.24 mmol, 0.12 equiv) and 5-aryl-2-formylpyrrole (0.2 mmol, 0.1 equiv). The flask was capped with analuminume-PTFE crimp cap, sealed, and evacuated and backfilled with nitrogen three times. To the flask was then added anhydrous toluene (2 mL, 0.1M in aldehyde) and piperidine (10 mL, 0.1 mmol,0.5 equiv). The flask was transferred to a pre-warmed oil bath set to 111 C and stirred for 2 h. After 2 h the flask was removed from theoil bath and cooled to room temperature and then to 0 C in a water-ice bath. To the flask was added hexanes (5 mL) and the flask was allowed to sit for an addition 10-30 min. The mixture was the filtered, and the precipitate was then triturated with hexanes to until the filtrate ran clear to provide the pure product as a red, blue,or purple solid depending on the substrate., 130-03-0

The synthetic route of 130-03-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zweig, Joshua E.; Ko, Tongil A.; Huang, Junrou; Newhouse, Timothy R.; Tetrahedron; vol. 75; 34; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Analyzing the synthesis route of 1423-61-6

1423-61-6 7-Bromobenzo[b]thiophene 12045538, abenzothiophene compound, is more and more widely used in various fields.

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1423-61-6, Preparation 1; 2-Benzo[]thiophen-7-yl-4,4,5,5-tetramethyl-[l,3,2]dioxaborolane; Combine 7-bromo-benzo[7?]thiophene (426 mg, 2 mmol), bis(pinacolato)diboron (756 mg, 3 mmol), [l,r-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (1 : 1) (81 mg, 0.1 mmol), potassium acetate (294 mg, 3 mmol) in dimethyl sulfoxide (DMSO) (10 mL) in a flask. Bubble nitrogen through the mixture for 5 min. Seal the flask and heat in an oil bath at 100 0C for 4 hours. Dilute the mixture with chloroform/isopropanol (3/1). Wash the solution with saturated aqueous sodium chloride. Dry the solution over sodium sulfate. Concentrate the solution in vacuo to a dark residue. Purify by column chromatography (hexane to 20 % ethyl acetate in hexane) to afford the title compound (342 mg, 66 %) as a colorless solid. MS (ES) m/z 261 [M+ 1]+.

1423-61-6 7-Bromobenzo[b]thiophene 12045538, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2008/76704; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Some tips on 5381-20-4

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, 1-Benzothiophene-3-carbaldehyde (4c) (164 mg, 1.00 mmol) in 1.0 ml of dry THF was initially introduced into a dry 25 ml Schlenk flask filled with argon and with a magnetic stirrer core and septum, and Zn(TMP)2.2LiCl.2MgCl2 dissolved in THF (1.5 ml, 0.37 M, 0.55 equivalent) was added dropwise at room temperature. After 40 min the metallization was complete (GC analysis of reaction samples to which a solution of I2 in THF had been added indicated a conversion of more than 98%). A solution of 4-EtO2CPh-I (331 mg, 1.2 equivalents), Pd(dba)2 (5 mol %) (dba=dibenzylideneacetone) and tri-ortho-furylphosphine (Tfp) (10 mol %) in dry THF (2.5 ml) was then slowly added. After 5 h the reaction was ended by addition of saturated NH4Cl solution (10 ml). The aqueous phase was extracted with ethyl acetate (5¡Á10 ml), dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by filter column chromatography (silica gel; CH2Cl2/pentane 1:1); 5c (208 mg, 67%) was obtained as a yellow, crystalline solid.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ludwig Maximilians Universitat Munchen; US2010/160632; (2010); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem