With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1034305-11-7,Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol,as a common compound, the synthetic route is as follows.
Second step: Synthesis of 2-[(5-bromo-2-fluorophenyl)(chloro)methyl]-1-benzothiophene Into an acetonitrile (10 ml) solution of 1-benzothien-2-yl(5-bromo-2-fluorophenyl)methanol (1.0 g) was dropwise added thionyl chloride (706 mg) at a temperature of 5C or lower, followed by stirring at 5.0 to 25.0C for 3.5 hours. The reaction mixture was subjected to distillation under reduced pressure to distill off the solvent and the residue was subjected to vacuum drying to obtain 2-[(5-bromo-2-fluorophenyl)(chloro)methyl]-1-benzothiophene [1.05 g, yield: 100%, purity: 99% (HPLC)]. 1H-NMR (CDCl3): delta 6.62 (1H, s), 6.98 (1H, dd), 7.22 (1H, s), 7.30-7.37 (2H, m), 7.45 (1H, m), 7.71 (1H, dd), 7.77 (1H, m), 7.81 (1H, dd)
1034305-11-7, As the paragraph descriping shows that 1034305-11-7 is playing an increasingly important role.
Reference£º
Patent; Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.; EP2105442; (2009); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem