With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
12252] A mixture of 150mg of methyl 5-aminobenzo[b] thiophene-2-carboxylate, 170 mg of chioroacetyl chloride, 304 mg of triethylamine, and 10 ml of tetrahydroffiran was stirred for 24 hours at room temperature. Tert-butyl methyl ether was added to the reaction mixture, and the residue was washed with water, 1 M hydrochloric acid, an aqueous saturated sodium hydrogen carbonate solution, and saturated saline, dried over magnesium sulfate, and concentrated under reduced pressure. The residues were subjected to silica gel column chromatography, thereby obtaining 160mg ofmethyl 5 -chloroacetylaminobenzo [b]thiophene-2-carboxylate(hereinafier, described as a ?compound 72 of the presentinvention?).12253] Compound 72 of the Present InventionCl -S 0-12254] ?H-NMR (CDC13) oe: 8.36 (br s, 1H), 8.27 (s, 1H),8.03 (s, 1H), 7.85-7.83 (m, 1H), 7.52-7.50 (m, 1H), 4.24 (s,2H), 3.95 (s, 3H).
20699-85-8, As the paragraph descriping shows that 20699-85-8 is playing an increasingly important role.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
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