Day: September 14, 2020

130-03-0, Benzo[b]thiophen-3(2H)-one is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred mixture of ketone 1a or 1b (3 mmol) and diarylpropargylic alcohols 2a-e (3 ml) in acetonitrile (3 ml) the corresponding catalyst (Table 1) was added and the reaction mixture was refluxed under argon for 1 h. After cooling, the solvent was distilled off in vacuo. The residue was purified by recrystallization from the corresponding solvent or by chromatography on silica gel using the light petroleum/ethyl acetate (8:1) system as an eluent.

130-03-0, 130-03-0 Benzo[b]thiophen-3(2H)-one 10986413, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Shirinian, Valerii Z.; Zavarzin, Igor V.; Leonova, Evgeniya S.; Markosyan, Ashot I.; Mendeleev Communications; vol. 25; 4; (2015); p. 262 – 263;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.310466-38-7,4-Fluorobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

EXAMPLE 56 [0349] Preparation of (2S)-3-[(2R,4R)-4-(4-Fluorobenzo[b]thiophen-2-yl)-2-methylpiperidinyl]-1-(1H-indol-4-yl)oxy-2-propanol oxalate. [CHEMMOL-00107] [0350] Preparation of N-t-Butoxycarbonyl-4-(4-fluorobenzo[b]thiophen-2-yl)-2-methyl-4-piperidinol. [0351] Scheme IA, Step A: To a solution of 4- and 6-fluorobenzo[b]thiophene (12.4 g, 81.7 mmol, prepared in example 55) in dry THF (415 mL) at -78 C. was added 1.6 M n-BuLi in hexanes (56.4 mL, 90.2 mmol). The solution was stirred at -78 C. for 1.5 h. N-t-butoxycarbonyl-2-methyl-4-piperidone (15.7 g, 73.5 mmol) dissolved in THF (40 mL) was added via a cannula at -78 C. The reaction mixture was stirred at -78 C. for 4 h. The reaction was then quenched with 300 mL of saturated aqueous NH4Cl solution. The mixture was extracted (2¡Á500 mL) with EtOAc. The combined organic layers were then dried over MgSO4 and filtered. The filtrate was concentrated and purified by medium pressure chromatography (15% EtOAc/hexanes) to give the title compound as a white foam (3.66 g, 14%). 1HNMR (CDCl3) 7.54 (d, J=8.8 Hz, 1H), 7.25 (s, 1H), 7.22 (m, 1H), 6.96 (dd, J=9.0, 8.1, 1H), 4.31 (distt, 1H), 3.85 (m, 1H), 3.18 (dt, J=13.0, 2.9 Hz, 1H), 2.02-1.82 (m, 1H), 1.64 (dd, J=14.2, 6.8, 1H), 1.54-1.44 (m, 11H), 1.28 (d, J=6.8 Hz, 3H), 310466-38-7

As the paragraph descriping shows that 310466-38-7 is playing an increasingly important role.

Reference£º
Patent; Hansen, Marvin Martin; He, John Xiaoqiang; Honigschmidt, Nicholas Allan; Koch, Daniel James; Kohn, Todd Jonathan; Rocco, Vincent Patrick; Spinazze, Patrick Gianpietro; Takeuchi, Kumiko; US2004/6229; (2004); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146137-92-0,Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

12434] A mixture of 1.00 g of methyl 5-trifluoromethyl- benzo[b]thiophene-2-carboxylate, 772 mg of hydrazine monohydrate, and 15 ml of ethanol was stirred for 12 hours under reflux. The reaction mixture was concentrated under reduced pressure, and tert-butyl methyl ether was added to the residues. The organic layer was washed with 1 M hydrochloric acid and saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were recrystallized from tert-butyl methyl ether and ethanol, thereby obtaining 595 mg of N-amino-5-trifluoromethyl- benzo[b]thiophene-2-carboxamide (hereinafier, described as a ?compound 161 of the present invention?). 12436] ?H-NMR (DMSO-D5) oe: 10.21 (br s, 1H), 8.37 (s,1H), 8.33-8.28 (m, 1H), 9.14 (s, 1H), 7.76-7.73 (m, 1H), 4.62(br s, 2H).

146137-92-0, The synthetic route of 146137-92-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

Compound TDI01116-2 (550 mg, 2.04 mmol) and bis(pinacolato)diboron (621 mg, 2.44 mmol) were dissolved in dioxane (20 mL), potassium acetate (600 mg, 6.12 mmol) and Pd(dppf)Cl2 (140 mg, 0.20 mmol) were added, purge with argon was performed for 3 times, and the reaction was placed in an oil bath at 80C overnight. Thin layer chromatography (petroleum ether : ethyl acetate= 10:1) indicated the reaction was complete. The reaction solution was cooled to room temperature, and concentrated under reduced pressure. The residue was separated and purified by column chromatography (petroleum ether : ethyl acetate= 20:1) to afford compound TDI01116-3 (600 mg, white solid, yield: 92.3%). 1H NMR (400 MHz, CDCl3) delta 8.35 (s, 1H), 8.06 (s, 1H), 7.87 (d, J = 8.0 Hz, 1H), 7.80 (d, J = 8.0 Hz, 1H), 3.95 (s, 3H), 1.38 (s, 12H).

360576-01-8, 360576-01-8 Methyl 6-bromobenzo[b]thiophene-2-carboxylate 22474078, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing Tide Pharmaceutical Co., Ltd.; Zhao, Yanping; Wang, Hongjun; Li, Gong; Jiang, Yuanyuan; Li, Xiang; Zhou, Liying; Liu, Yanan; (106 pag.)EP3421464; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 10A 2-Benzo[b]thiophen-5-yl-4,4,5,5-tetramethyl-[3.2.1]dioxaborolane A mixture of 5-bromo-benzo[b]thiophene (Maybridge, 4.26 g, 0.0200 mol), bis(pinacolato)diboron (Aldrich, 6.09 g, 0.0240 mol) and potassium acetate (Aldrich, 2.94 g, 0.0300 mol) in 1,4-dioxane (Aldrich, 50 mL) was degassed and purged with N2 three times. [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) PdCl2(dppf).CH2Cl2 (300 mg, 0.4 mmol, Aldrich) was and the solution was heated to 100 C. for 20 hours. The mixture was then cooled to room temperature, diluted with 300 mL of EtOAc and washed with brine (2*20 mL). The organic solution was concentrated under reduced pressure and the residue was chromatographed to provide the title product. 1H NMR (300 MHz, CDCl3) delta 1.36-1.41 (S, 12H), 7.35 (d, J=5.50 Hz, 1H), 7.42 (d, J=5.70 Hz, 1H), 7.75 (d, J=8.14 Hz, 1H), 7.89 (d, J=8.14 Hz, 1H), 8.31 (s, 1H) ppm. MS (DCI/NH3) m/z 278 (M+H)+.

4923-87-9, The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ji, Jianguo; Li, Tao; Lynch, Christopher L.; Gopalakrishnan, Murali; US2008/45539; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

95-15-8,95-15-8, Thianaphthene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen protection, in a four-necked flask equipped with a mechanical stirring and a thermometer, 20.1 g of benzothiophene and 180 mL of 2-methyltetrahydrofuran were stirred and dissolved, and the temperature was lowered to -40–35 C, and 90 ml of butyllithium was added thereto. 3 hours after the reaction at the temperature, 40.3 g of 2-fluoro-5-bromobenzaldehyde was added. After the reaction was completed at this temperature for 10 hours, the temperature was raised to room temperature, and the pH was adjusted to 7 by adding hydrochloric acid. 2. Under a nitrogen atmosphere, Compound 2 and n-hexane were added to a four-necked flask equipped with a mechanical stirring and a thermometer, and the mixture was stirred and dissolved. Then, trifluoroacetic acid and triphenylsilane (5 eq) were added, and then reacted at -10 C for 1 hour. After the completion of the monitoring reaction, the temperature was raised to room temperature, and the target compound was obtained as a white solid, 41 g.The yield in two steps was 81%.

95-15-8 Thianaphthene 7221, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Ruifuxin Jiangsu Pharmaceutical Co., Ltd.; Li Jianxin; Zhao Datong; Huang Jian; Xu Xiangyu; Zhang Zhiguo; Wang Jianfa; (11 pag.)CN108623558; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

12252] A mixture of 150mg of methyl 5-aminobenzo[b] thiophene-2-carboxylate, 170 mg of chioroacetyl chloride, 304 mg of triethylamine, and 10 ml of tetrahydroffiran was stirred for 24 hours at room temperature. Tert-butyl methyl ether was added to the reaction mixture, and the residue was washed with water, 1 M hydrochloric acid, an aqueous saturated sodium hydrogen carbonate solution, and saturated saline, dried over magnesium sulfate, and concentrated under reduced pressure. The residues were subjected to silica gel column chromatography, thereby obtaining 160mg ofmethyl 5 -chloroacetylaminobenzo [b]thiophene-2-carboxylate(hereinafier, described as a ?compound 72 of the presentinvention?).12253] Compound 72 of the Present InventionCl -S 0-12254] ?H-NMR (CDC13) oe: 8.36 (br s, 1H), 8.27 (s, 1H),8.03 (s, 1H), 7.85-7.83 (m, 1H), 7.52-7.50 (m, 1H), 4.24 (s,2H), 3.95 (s, 3H).

20699-85-8, As the paragraph descriping shows that 20699-85-8 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

200 g of dichloroethane,50 g of 3 (2H) -thianaphthene-1,1-dioxide,39 g of malononitrile,0.5 g of carbonyl iron powder into the reactor, stirring,Heated to the return state (80 ~ 82 ) began to heat,Reaction for about 6 h, TLC detection,3 (2H) -thianaphthene-1,1-dioxide has disappeared,Insulation end, down to room temperature, add water 200g,Stirring 10min, standing, stratification, remove the water layer,Began to heat up the recovery of dichloroethane,The resulting concentrate was nitrile, with a purity of 96.4% and weighing 60.2 g.

1127-35-1, 1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu Daobo Chemical Co., Ltd.; Liu Xuefeng; Xu Song; Wang Gang; Guo Weicheng; (8 pag.)CN106675082; (2017); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

A solution of 4.0 g (14.8 mmol) of methyl 6-bromo-1-benzothiophene-2-carboxylate in 40 ml of a 1:1 mixture of THF and 2 N potassium hydroxide solution is stirred at room temperature for 2 h. The solvent is removed in vacuo, and the residue is acidified with concentrated hydrochloric acid. The resulting precipitate is filtered off with suction, washed with water and dried in vacuo at 50 C. 3.55 g (93.5% of theory) of the desired product are obtained. 1H-NMR (400 MHz, DMSO-d6): delta=13.48 (broad s, 1H), 8.38 (s, 1H), 8.22 (s, 1H), 7.96 (d, 1H), 7.63 (m, 1H). HPLC (method 1): Rt=4.5 min., 360576-01-8

The synthetic route of 360576-01-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Luithle, Joachim; Bob, Frank-Gerhard; Erb, Christina; Schnizler, Katrin; Flessner, Timo; Kampen, Marja van; Methfessel, Christoph; US2007/37844; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

20699-86-9, Methyl 5-nitrobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: Methyl-5-amino-benzo[b]thiophene-2-carboxylate (588) A suspension of 584 (3.52 g, 14.8 mmol) in methanol (100 ml) was treated with Fe powder (6.63 g, 118.7 mmol). The resulting suspension was heated to reflux, and 12M HCl (8.5 ml) was slowly added over 15 min. The resulting green dark suspension was refluxed for an additional 3 h, then cooled and concentrated. The residue was taken up in EtOAc and washed with saturated aqueous NaHCO3, then brine, dried over MgSO4, filtered and concentrated to afford (2.57 g, 84%). 1H NMR: (DMSO) delta (ppm): 7.92 (s, 1H), 7.65 (d, J=8.8 Hz, 1H), 7.05 (d, J=1.5 H, 1H), 6.88 (dd, J=1.8, 8.4 Hz, 1H), 5.27 (s, 2H), 3.85 (s, 3H). LRMS: 207.0 (Calc.); 208.1 (found).

20699-86-9, 20699-86-9 Methyl 5-nitrobenzo[b]thiophene-2-carboxylate 1489057, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; MethylGene, Inc.; US2005/288282; (2005); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem