With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23046-03-9,5,6-Dimethoxybenzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.
REFERENCE EXAMPLE 2 5,6-Dimethoxybenzothiophen-2-nitrile The amide compound prepared in Reference Example 1 (13.5 g, 56.9 mmol) was dissolved in pyridine (70 mL). To the solution at 10 C. or lower was added dropwise trifluoroacetic anhydride (40 mL). After stirring at 0 C. for 1 hour, water (200 mL) was added and the precipitated crystals were collected by filtration to give the title compound (11.2 g, 90%) as opalescent crystals. Melting point=121, to 123 C. 1H-NMR (DMSO-d6, 270 MHz) delta=8.13 (bs, 1H), 7.66 (s, 1H), 7.48 (s, 1H), 3.88 and 3.85 (2s, each 3H)., 23046-03-9
23046-03-9 5,6-Dimethoxybenzo[b]thiophene-2-carboxylic acid 268620, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; Tsunoda, Hidetoshi; Fukuzawa, Nobuyuki; Chiba, Kyoko; Nakao, Toshifumi; Asada, Noriaki; Takebayashi, Nozomi; Kibayashi, Kenji; Migita, Hideyuki; Morikawa, Maki; US2003/109570; (2003); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem