With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
12141] A mixture of 500 mg of methyl 6-bromobenzo[b] thiophene-2-carboxylate, 877mg of tributyl vinyl tin, 213mg of tetrakis(triphenylphosphine)palladium (0), and 4 ml of toluene was stirred for 5 hours at 1100 C. under a nitrogen atmosphere. After the reaction mixture was cooled to room temperature, an aqueous saturated ammonium chloride solution and ethyl acetate were added thereto, and insoluble matter was separated by filtration. Extraction was performed on the filtrate by using ethyl acetate, and the organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel colunm chromatography, thereby obtaining 229mg of methyl 6-vinylbenzo[b]thiophene-2-car- boxylate (hereinafier, described as a ?compound 32 of the present invention?).12142] Compound 32 of the Present Invention%_)%%%%%L5/ _12143] ?H-NMR (CDC13) oe: 8.03 (s, 1H), 7.84-7.81 (m,2H), 7.52-7.50 (m, 1H), 6.82 (dd, 1H, J=17.6, 11.0Hz), 5.87(d, 1H, J=17.6 Hz), 5.36 (d, 1H, J=11.0 Hz), 3.95 (s, 3H).
360576-01-8, The synthetic route of 360576-01-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
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