With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
5381-20-4, General procedure: To a suspension of Yb(OTf)3 (207 mg,0.334 mmol) and TMSCl (0.850 mL, 6.70 mmol) in CH2Cl2 (4 mL) was added dropwise a solution ofaldehyde 3a (50.1 mg, 0.330 mmol) and Et3N (1.86 mL, 13.3 mmol) in CH2Cl2 (1 mL) at 0 C. The mixturewas stirred at room temperature for 24 h. Saturated aqueous NaHCO3 solution was added at 0 C, and thenthe resulting mixture was stirred at room temperature for 30 min. After separation, the aqueous layer wasextracted with CH2Cl2. The combined organic layers were washed with brine and dried over MgSO4. Afterremoval of the solvent, the residue was chromatographed. Elution with a 2:1 mixture of hexane-EtOAcfurnished 4a4 (34.1 mg, 58%) as a color less oil.
5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various.
Reference£º
Article; Kagawa, Natsuko; Sasaki, Yoshiko; Sakaguchi, Shoko; Nagatomo, Ayumi; Kojima, Hideo; Toyota, Masahiro; Heterocycles; vol. 8; 2; (2014); p. 1581 – 1585;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem