Day: September 8, 2020

6314-28-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 3a-3o (1.94 mmol) in anhydrous dichloromethane(20.0 mL) and HATU (2.33 mmol) in the presence of DIEA(3.89 mmol), tert-butylpiperazine-1-carboxylate (2.14 mmol) wasadded and stirred for 12 h. After completion, dilute hydrochloricacid solution was added, extracted with dichloromethane andwashed with saturated sodium carbonate solution three times. Thecombined organic layers were washed with brine and dried with sodium sulfate, filtered, concentrated, and purified by silica gelchromatography with petroleum ether/ethyl acetate as eluent togive pure 4a-4o [34].

The synthetic route of 6314-28-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cai, Guiping; Yu, Wenying; Song, Dongmei; Zhang, Wenda; Guo, Jianpeng; Zhu, Jiawen; Ren, Yuhao; Kong, Lingyi; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 236 – 251;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

4521-30-6, Benzo[b]thiophen-2-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4521-30-6

STEP A: Ethanesulfonic acid benzo[b]thiophen-2-ylamide Ethanesulfonic acid benzo[b]thiophen-2-ylamide was prepared by reacting benzo[b]thiophen-2-ylamine and 4-ethanesulfonyl chloride, according to the procedure as described in Example 1, STEP C above.

The synthetic route of 4521-30-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Acton, Paul D.; Hlasta, Dennis J.; Matthews, Jay M.; McNally, James J.; US2010/15053; (2010); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

95-15-8, Thianaphthene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

95-15-8, EXAMPLE 11 Preparation of Benzo[b]thiophene-2-carboxaldehyde STR100 Butyllithium (54 mL, 134 mmol) is added dropwise to a solution of N,N,N’,N’-tetramethylethylenediamine (15.57 g, 134 mmol) in tetrahydrofuran under nitrogen at 0 C. The reaction mixture is treated dropwise with a solution of benzothiophene (15.00 g, 112 mmol) in tetrahydrofuran, warmed to room temperature, treated with additional N,N,N’,N’-tetramethylethylenediamine (15.57 g, 134 mmol) and butyllithium (54 mL, 134 mmol), stirred at room temperature for 13 hours, cooled to 0 C., treated with N,N-dimethylformamide (24.40 g, 336 mmol), warmed to room temperature, stirred for five hours, poured into one molar hydrochloric acid and extracted with ether. The combined organic extracts are washed sequentially with water and brine, dried over Na2 SO4 and concentrated in vacuo to obtain an orange oil. Flash chromatography of the oil using silica gel and a 15% ethyl acetate in hexane 25 solution gives the title product as an orange oil (12.51 g, 69%).

The synthetic route of 95-15-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; American Cyanamid Company; US5492925; (1996); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, General procedure: To a suspension of Yb(OTf)3 (207 mg,0.334 mmol) and TMSCl (0.850 mL, 6.70 mmol) in CH2Cl2 (4 mL) was added dropwise a solution ofaldehyde 3a (50.1 mg, 0.330 mmol) and Et3N (1.86 mL, 13.3 mmol) in CH2Cl2 (1 mL) at 0 C. The mixturewas stirred at room temperature for 24 h. Saturated aqueous NaHCO3 solution was added at 0 C, and thenthe resulting mixture was stirred at room temperature for 30 min. After separation, the aqueous layer wasextracted with CH2Cl2. The combined organic layers were washed with brine and dried over MgSO4. Afterremoval of the solvent, the residue was chromatographed. Elution with a 2:1 mixture of hexane-EtOAcfurnished 4a4 (34.1 mg, 58%) as a color less oil.

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Kagawa, Natsuko; Sasaki, Yoshiko; Sakaguchi, Shoko; Nagatomo, Ayumi; Kojima, Hideo; Toyota, Masahiro; Heterocycles; vol. 8; 2; (2014); p. 1581 – 1585;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

95-15-8, Thianaphthene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a CH2Cl2 solution (50 mL) of benzo[b]thiophene (14, 5.00 g, 37.3 mmol) and KOAc (7.30 g, 74.6 mmol) was added Br2 (3.8 mL, 74.6 mmol) at 20 C, and the solution was heated under reflux for 24 h. To the solution was added a satd solution of Na2S2O3 and NaHCO3. The organic and the aqueous layer were separated, and the latter was extracted with CH2Cl2 (3*30 mL). The combined organic layers were dried (Na2SO4), filtered, and concentrated in vacuo. The residue was purified by flash silica column chromatography (pure heptanes) to yield 15a as a white solid (9.1 g, 84%). The spectroscopic data were identical with those reported.17,18, 95-15-8

95-15-8 Thianaphthene 7221, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Tengho Toguem, Serge-Mitherand; Malik, Imran; Hussain, Munawar; Iqbal, Jamshed; Villinger, Alexander; Langer, Peter; Tetrahedron; vol. 69; 1; (2013); p. 160 – 173;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6; Preparation of Compound 49; Step A – Synthesis of Compound 49 A; A solution of 7-bromothiophene (8.0 g, 37.5 mmol) in ether (50 mL) was cooled to -78 C and treated dropwise with n-BuLi (1.6 M solution in hexanes, 1.0 eq.) and the resulting reaction was allowed to stir at -78 C for 20 minutes. The reaction mixture was then diluted with DMF (dry 5.4 g, 67.4 mmol) and allowed to stirat -78 0C for 1 hour. The reaction mixture was then diluted with water and extracted into ether. The combined organic layers were dried (MgSO4), filtered, concentrated in vacuo and purified using flash column chromatography on silica gel to provide compound 49A as a colorless liquid.; Example 7; Preparation of Compound 52; Step A – Synthesis of Compound 52A; A solution of 7-bromothiophene (8.0 g, 37.5 mmol) in ether (50 mL) was cooled to -78 C, then n-BuLi (1.6 M soln in hexanes, 1.0 eq.) was added dropwise and the resulting reaction was allowed to stir at -78 0C for 20 minutes. The reaction mixture was diluted with DMF (dry 5.4 g, 67.4 mmol) and allowed to stir at -78 0C for 1 hour. The reaction mixture was then quenched with water and the resulting solution was extracted into ether. The combined organic layers were dried (MgSO4), filtered, and concentrated in vacuo to provide a crude residue which was purified using flash column chromatography on silica gel to provide compound 52A as a colorless liquid., 1423-61-6

1423-61-6 7-Bromobenzo[b]thiophene 12045538, abenzothiophene compound, is more and more widely used in various.

Reference£º
Patent; SCHERING CORPORATION; WO2008/82484; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

6179-28-8,6179-28-8, Benzo[b]thiophen-6-ylmethanol is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Phosphorus oxybromide (2.7 g) was added to a solution of 6-hydroxymethylbenzo[b]thiophene (0.7 g) in ether (50 ml) at reflux. After 3 h at reflux the solution was washed with water, aqueous sodium hydrogen carbonate, and brine, dried (MgSO4) and evaporated to give the title compound (0.7 g).

As the paragraph descriping shows that 6179-28-8 is playing an increasingly important role.

Reference£º
Patent; Bruton, Gordon; Faller, Andrew; Orlek, Barry Sidney; Rana, Kishore Kalidas; Walker, Graham; US2003/199571; (2003); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

12141] A mixture of 500 mg of methyl 6-bromobenzo[b] thiophene-2-carboxylate, 877mg of tributyl vinyl tin, 213mg of tetrakis(triphenylphosphine)palladium (0), and 4 ml of toluene was stirred for 5 hours at 1100 C. under a nitrogen atmosphere. After the reaction mixture was cooled to room temperature, an aqueous saturated ammonium chloride solution and ethyl acetate were added thereto, and insoluble matter was separated by filtration. Extraction was performed on the filtrate by using ethyl acetate, and the organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel colunm chromatography, thereby obtaining 229mg of methyl 6-vinylbenzo[b]thiophene-2-car- boxylate (hereinafier, described as a ?compound 32 of the present invention?).12142] Compound 32 of the Present Invention%_)%%%%%L5/ _12143] ?H-NMR (CDC13) oe: 8.03 (s, 1H), 7.84-7.81 (m,2H), 7.52-7.50 (m, 1H), 6.82 (dd, 1H, J=17.6, 11.0Hz), 5.87(d, 1H, J=17.6 Hz), 5.36 (d, 1H, J=11.0 Hz), 3.95 (s, 3H).

360576-01-8, The synthetic route of 360576-01-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, [0359j To a solution of 2-D (200 mg, 0.71 mmol) in anhydrous ethanol (30 mL) was added benzo[b]thiophene-3-carbaldehyde (2-E) (150 mg, 0.92 mmol) and AcOH (0.1 mL), the mixture was stirred at 50C for 15 h. Then the mixture was allowed to cool to rt and a white precipitate was formed in the solution. The precipitate was filtered and washed with EtOAc to afford compound 200 as a white solid (118 mg, 38.9%). +ESI-MS:mlz 428.0 [M+H].

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Patent; ALIOS BIOPHARMA, INC.; WANG, Guangyi; BEIGELMAN, Leonid; TRUONG, Anh; NAPOLITANO, Carmela; ANDREOTTI, Daniele; HE, Haiying; WO2014/31784; (2014); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, General procedure: Sulfanilamide (1.0 equiv) was dissolved in dry MeOH and theappropriate aldehyde (1.0 equiv) was added to the reaction. Thesolution was stirred until the formation of a precipitate was completedwhich was collected by filtration, washed with ice-coldMeOH and dried under vacuo to afford the desired compounds 1-17.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Sarikaya, Busra; Ceruso, Mariangela; Carta, Fabrizio; Supuran, Claudiu T.; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5883 – 5890;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem