With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
General procedure: Into the mixture of difluoromethyltriphenylphosphoniumbromide (236 mg, 0.6 mmol), aldehyde (0.2 mmol) and DBU(90 mL, 0.6 mmol) was added DMF (2 mL) under N2. The resulting mixture was stirred at 50 C for 4 h. After being cooled to room temperature, the solution was diluted with CH2Cl2 (10 mL) andwashed with water (5 mL x 2). The organic phase was dried over sodium sulfate. The solvent was removed by concentration and the residue was subjected to column chromatography to give the pure product., 5381-20-4
The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Li, Qiang; Lin, Jin-Hong; Deng, Zu-Yong; Zheng, Jian; Cai, Ji; Xiao, Ji-Chang; Journal of Fluorine Chemistry; vol. 163; (2014); p. 38 – 41;,
Benzothiophene – Wikipedia
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