With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.
A solution of 7-bromobenzo[b]thiophene (6 g, 28.6 mmol) in tetrahydrofuran (60 mL) was cooled to -60 C. Lithium diisopropylamide (2M in THF, 43 mL, 86 mmol) was added dropwise and stirred at -60 C for 1 hour. Then N,N-dimethylformamide (6.3 g, 85.8 mmol) was added and stirred at -60 C for 2 hours. TLC showed the reaction was completed. The reaction was quenched by water and extracted with dichloromethane (30 mL x 3). The combined organic phases were washed with brine, dried over sodium sulfate and concentrated in vacuum. The residue was purified by silica gel column chromatography [petroleum ether/ethyl acetate=15: l ] to afford compound B-110 (5.2 g, 76% yield) as yellow solid. GCMS: M= 241 .9, tR= 10.655., 1423-61-6
As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.
Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem