4521-30-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4521-30-6,Benzo[b]thiophen-2-amine,as a common compound, the synthetic route is as follows.
EXAMPLE 16 2-(4-Pyridinylamino)benzo[b]thiophene A solution of 2-aminobenzo[b]thiophene1 (10 g) and 4-chloropyridine hydrochloride (12 g) in 100 mL of 1-methyl-2-pyrrolidinone was stirred at 75-80 C. for 1.5 hours. After cooling, the reaction mixture was stirred with water and washed with ether, and the layers were separated from each other. The aqueous layer was basified with 30% aqueous ammonium hydroxide. The precipitate was collected, washed with water and collected again. Trituration with acetonitrile afforded 6 g of a light tan solid, mp 254-258 C. (dec.). Recrystallization of 3 g from acetonitrile afforded 1.1 g of flocculent tan crystals, mp 258-260 C. (dec.). 1 G. W. Stacy, et al., J. Org. Chem., 30, 4074 (1965). ANALYSIS; Calculated for C13 H10 N2 S: 69.00% C; 4.45% H; 12.38% N; Found: 68.72% C; 4.27% H; 12.42% N.
As the paragraph descriping shows that 4521-30-6 is playing an increasingly important role.
Reference£º
Patent; Hoechst-Roussel Pharmaceuticals Incorporated; US5328920; (1994); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem