Day: September 4, 2020

89673-36-9, tert-Butyl benzo[b]thiophen-2-ylcarbamate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,89673-36-9

b; 1-Benzothiophen-2-amine[00118] To a solution of 1 ,1-Dimethylethyl 1-benzothien-2-ylcarbamate (1.0 g, 4.01 mmoles) in DCM (10 ml_) was added TFA (2.0 mL) and stirred for 12 h. The reaction mixture was concentrated, and the resulted residue was redissolved in DCM and washed with 1 N NaOH (2×50 mL), brine and dried over Na2SO4. The mixture was filtered and concentrated to afford pure product (0.54 g) in 91 % yield. LCMS (m/z): 150.0 (M+H).

The synthetic route of 89673-36-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NPS PHARMACEUTICALS, INC.; GLAXOSMITHKLINE; WO2006/41968; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

[0626j To a solution of benzo[b]thiophene-3-carboxaldehyde (8-A) (3.22 g, 20 mmol) in THF (20 mL), vinyl magnesium bromide (20 mmol, 1M in Et20) was added dropwise at rt. The mixture was stirred for 2 h at rt. The mixture was treated with aqueous NH4C1 and extracted with EA. The organic phase was concentrated and the residue was purified by column chromatography on silica gel (PE:EA = 50:1) to afford 9-D (2.50 g, 65.7

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various.

Reference£º
Patent; ALIOS BIOPHARMA, INC.; WANG, Guangyi; BEIGELMAN, Leonid; TRUONG, Anh; NAPOLITANO, Carmela; ANDREOTTI, Daniele; HE, Haiying; WO2014/31784; (2014); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6314-28-9, benzo[b]thiophene-2-carboxylic acid (159 mg, 0.892 mmol), 2-amino-biphenyl (156 mg, 0.922 mmol),DCC (393 mg, 1.90mmol)and DMAP (26 mg, 0.21 mmol)was dissolved in dichloromethane (20 mL) and stirred for 14 hours at room temperature. Thin film chromatography (TLC) in verifying, new the spot location changes accordingly once created, after adding water to the composition, a reaction mixture of a, die chloro methane at extracted times 2. Extracted organic layer are dried, in the form of tetrabutylammonium magnesium, was, concentrating it under reduced pressure. Concentrated reaction mixture column chromatography (silica gel, ethyl acetate/n = 1/9-hexanediol) for purifying the white solid thereby, a desired compound (102 mg, 35%) is obtained.

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

Reference£º
Patent; Korea research Institute of Chemical Technology; Han, Soo Bong; Achari, Ragavendra; Kim, Mi Hyeon; Jong, Yong Sik; Kim, Pil Ho; (119 pag.)KR2016/21163; (2016); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of benzo[b]thiophene-2-carbaldehyde (3 g, 18.6 mmol) and core 1 (4 g, 12.4 mmol) in anhydrous CH3CN (100 mL) was added TFA (424 mg 3.7 mmol) at 25C. The mixture was agitated for 6 hours. The reaction mixture became a clear solution and then a solid appeared. The solid was collected by filtration and washed with CH3CN to provide 9a (5.4 g, 69 % yield)

3541-37-5, As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; TONG, Ling; YU, Wensheng; KOZLOWSKI, Joseph A.; CHEN, Lei; SELYUTIN, Oleg; KIM, Seong Heon; DWYER, Michael; HU, Bin; ZHONG, Bin; WAI, Dahai; HAO, Jinglai; SHEN, Changmao; LEI, Zhixin; WANG, Weijun; WO2014/110688; (2014); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

4521-30-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4521-30-6,Benzo[b]thiophen-2-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 16 2-(4-Pyridinylamino)benzo[b]thiophene A solution of 2-aminobenzo[b]thiophene1 (10 g) and 4-chloropyridine hydrochloride (12 g) in 100 mL of 1-methyl-2-pyrrolidinone was stirred at 75-80 C. for 1.5 hours. After cooling, the reaction mixture was stirred with water and washed with ether, and the layers were separated from each other. The aqueous layer was basified with 30% aqueous ammonium hydroxide. The precipitate was collected, washed with water and collected again. Trituration with acetonitrile afforded 6 g of a light tan solid, mp 254-258 C. (dec.). Recrystallization of 3 g from acetonitrile afforded 1.1 g of flocculent tan crystals, mp 258-260 C. (dec.). 1 G. W. Stacy, et al., J. Org. Chem., 30, 4074 (1965). ANALYSIS; Calculated for C13 H10 N2 S: 69.00% C; 4.45% H; 12.38% N; Found: 68.72% C; 4.27% H; 12.42% N.

As the paragraph descriping shows that 4521-30-6 is playing an increasingly important role.

Reference£º
Patent; Hoechst-Roussel Pharmaceuticals Incorporated; US5328920; (1994); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

360576-01-8, Methyl 6-bromobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 500 mg of methyl 6-bromobenzo[b]thiophene-2-carboxylate, 494 mg of 4-(trifluoromethoxy)phenylboronicacid, 407 mg of lithium chloride, 352 mg of sodium carbonate, 107 mg of tetrakis(triphenylphosphine)palladium(0), 20 ml of 1,4-dioxane, and 10 ml of water was stirred for 3.5 hours at 100C. After being cooled to room temperature,the reaction mixture was concentrated under reduced pressure. Chloroform was added to the residues, and insolublematter was separated by filtration. After water was added to the filtrate, extraction was performed using chloroform. Theorganic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reducedpressure. The residues were subjected to silica gel column chromatography, thereby obtaining 509 mg of methyl 6-(4-trifluoromethoxyphenyl)benzo[b]thiophene-2-caboxylate., 360576-01-8

360576-01-8 Methyl 6-bromobenzo[b]thiophene-2-carboxylate 22474078, abenzothiophene compound, is more and more widely used in various.

Reference£º
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2926660; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Combine 7-bromo-benzo[b] thiophene (426 mg, 2 mmol), bis-(pinacolato)- diboron (756 mg, 3 mmol), Pd(dppf)Cl2 (81 mg, 0.1 mmol), potassium acetate (294 mg, 3 mmol) in dimethyl sulfoxide (DMSO) (10 mL) in a flask. Bubble nitrogen through the mixture for 5 minutes (min). Seal the flask and place it into an oil bath to heat at 100 0C for 4 hours (h). Dilute the mixture with chloroform/isopropyl alcohol (IPA) (3/1). Wash the solution with aqueous saturated sodium chloride. Dry over sodium sulfate. Concentrate the solution in vacuo to a dark residue. Purify by column chromatography (hexane-^ 20 % ethyl acetate in hexane) to give the title compound as a colorless solid (342 mg, 66 %). MS (ES) m/z 261 [M+l]+., 1423-61-6

The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2008/144223; (2008); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

12157] A mixture of 750 mg of methyl 6-bromobenzo[b] thiophene-2-carboxylate, 438mg of phenyl boronic acid, 610 mg of lithium chloride, 528mg of sodium carbonate, 160mg of tetrakis(triphenylphosphine)palladium (0), 30 ml of 1,4- dioxane, and 15 ml of water was stirred for 4 hours at 100 C. under a nitrogen atmosphere. After being cooled to room temperature, the reaction mixture was concentrated under reduced pressure. Chloroform and water were added to the residues, and insoluble matter was separated by filtration. The aqueous layer was extracted twice by using chloroform, and the collected organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel colunm chromatography, thereby obtaining 475mg ofmethyl 6-phenylbenzo[b]thiophene-2-carboxylate (hereinafter, described as a ?compound 36 of the present invention?).12158] Compound 36 of the present inventionj2159] ?H-NMR (CDC13) oe: 8.08 (s, 1H), 8.07-8.06 (m, 1H), 7.95-7.93 (m, 1H), 7.67-7.65 (m, 3H), 7.49-7.47 (m, 2H), 7.40-7.38 (m, 1H), 3.96 (s, 3H).

360576-01-8, 360576-01-8 Methyl 6-bromobenzo[b]thiophene-2-carboxylate 22474078, abenzothiophene compound, is more and more widely used in various.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.

To the stirring solution of compoundS2(12.0 g, 56.3 mmol) in THF (300 mL) was added isopropylmagnesium chloride (150 mL, 1.3 M in THF) drop wise at 0oC under nitrogen. The resulting mixture was stirred at rt overnight. To the reaction mixture was addedN,N-dimethylformamide (30.0 mL) drop wise. The resulting solution was stirred for 30 min at rt. The reaction was then quenched by the addition of H2O (500 mL). The mixture was extracted with ethyl acetate (3 x 500 mL), and the organic layers were combined and concentrated under vacuum. The residue was applied onto a silica gel column, eluting with ethyl acetate/petroleum ether (1:50 v/v). CompoundS2was obtained as a yellow solid (6.90 g, 68 % yield).1H NMR (400 MHz, Chloroform-d) delta 10.07 (s, 1H), 8.25 (s, 1H), 7.95 (d,J= 8.6 Hz, 1H), 7.83 (d,J= 8.6 Hz, 1H), 7.53 (d,J= 5.1 Hz, 1H), 7.43 (d,J= 6.1 Hz, 1H).

4923-87-9, As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.

Reference£º
Article; Huang, Hui; Winters, Michael P.; Meegalla, Sanath K.; Arnoult, Eric; Paul Lee; Zhao, Shuyuan; Martin, Tonya; Rady, Brian; Liu, Jianying; Towers, Meghan; Otieno, Monicah; Xu, Fran; Lim, Heng Keang; Silva, Jose; Pocai, Alessandro; Player, Mark R.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 3; (2018); p. 429 – 436;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

A mixture of thianaphthene-3-carboxaldehyde (0.5 g, 3.08 mmol), 3-aminocrotonitrile (0.554 mL, 6.74 mmol) and acetic acid (0.076 mL, 3.08 mmol) in isopropyl alcohol (10 mL) was stirred at 100C for 18 hours. The mixture was allowed to cool to RT and concentrated. The residue was basified with aq. sodium bicarbonate, and the resulting solid was filtered off and washed with cold water and ethyl ether. The desired product was obtained as a light-yellow solid (0.738 g, 82 %). 1H-NMR (400 MHz, DMSO-d6) delta = 2.06 (s, 6H), 5.00 (s, 1H), 7.36-7.46 (m, 1H), 7.65 (s, 1H), 7.89 (d, 1H), 8.03 (d, 1H), 9.67 (s, 1H). HPLC-MS: Rt 3.878 min, m/z 292.0 (MH+).

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Oncostellae, S.L.; KURZ, Guido; CAMACHO GOMEZ, Juan; (123 pag.)EP3480201; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem