Day: September 3, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.,6314-28-9

General procedure: Thionyl chloride (9 mL) was added to the carboxylic acid (1.0 equiv, 10.0 mmol) and the mixture wasrefluxed for 2 h. The solution was then concentrated in vacuo. An oven-dried round-bottomed flask(100 mL) equipped with a stir bar was charged with glutarimide (909.4 mg, 0.91 equiv, 8.04 mmol), acyl chloride (1.0 equiv, 8.84 mmol), 4-dimethylaminopyridine (DMAP, 280.4 mg, 0.25 equiv, 2.5mmol) and dichloromethane (50 mL). Triethylamine (typically, 2.0 equiv) was added dropwise to the reaction mixture with vigorous stirring at 0 C, and the reaction mixture was stirred overnight at room temperature. After the indicated time, the reaction mixture was diluted with Et2O (20 mL) and filtered.The organic layer was washed with HCl (1.0 N, 30 mL), brine (30 mL), dried, and concentrated. The residue was purified by recrystallization or chromatography on silica gel to afford the corresponding amide.

6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Lee, Shao-Chi; Guo, Lin; Yue, Huifeng; Liao, Hsuan-Hung; Rueping, Magnus; Synlett; vol. 28; 19; (2017); p. 2594 – 2598;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5381-20-4

General procedure: Benzo[b]thiophene-3-carbaldehyde (40 mg, 0.25 mmol, 1.0 equiv),Pd(TFA) 2 (4.2 mg, 5 mol%), (4-FC 6 H 4 ) 3 P (9.5 mg, 12 mol%), DPEphos (8mg, 6 mol%), and Cs 2 CO 3 (122 mg, 0.375 mmol) were placed in atransparent Schlenk tube equipped with a stirring bar. The tube wasevacuated and filled with argon for three times. Degassed DMF (2.5mL) and tert-butyl bromide (51 mg, 0.375 mmol, 1.5 equiv) were add-ed via a gastight syringe. The reaction mixture was stirred under theirradiation of 36 W blue LEDs (distance app. 2.0-3.0 cm from thebulb) at r.t. for 24 h. The mixture was quenched with brine and ex-tracted with EtOAc (3 ¡Á 10 mL). The organic layers were combinedand concentrated under reduced pressure. The product was purifiedby flash column chromatography on silica gel using PE or a mixture of PEand EtOAc (10:1 v/v) as eluent; yield: 50.1 mg (92%); pale yellow liquid.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Wang, Guang-Zu; Shang, Rui; Fu, Yao; Synthesis; vol. 50; 15; (2018); p. 2908 – 2914;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4923-87-9

To a 50 mL three-necked flask were added 5.17 mL (32 mmol) of 2-ethylhexan-1-amine, 4.50 mg (21 mmol) of 5-bromobenzo [b] thiophene, 31.17 g (8.5 mmol) of K 2 CO 3, 0.730 g mmol), 10 mL of DMSO was added, and the oil bath was set at 40 C. After N2 bubbling was carried out for 60 minutes, 0.807 g (4.3 mmol) of CuI,And then the oil bath was heated at 130 C. and stirred. The color change of the solution during that time was blue ? purple ? navy blue. After 68 hours,The mixture was poured into a separatory funnel with 100 mL of ethyl acetate,Wash the solution five times with saturated brine (100 mL), extract the origin with 100 mL of silica gel, dry the organic layer with magnesium sulfate,The solvent was removed under reduced pressure to obtain a yellow viscous substance.Thereafter, using 350 mL of silica gel, using hexane: toluene = 1: 1 as a developing solvent,Purification by column chromatography (Rf = 2.8) gave 3.0 g of the desired product. Yield 3.0 g(Yield 55%)

The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; National Yamagata University; Sasabe, Hisahiro; Kidosaki, Junji; Sano, Kenshi; Yuya, Wataru; (22 pag.)JP2018/127425; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20532-33-6,5-Chlorobenzothiophene,as a common compound, the synthetic route is as follows.

[000270] To a solution of 5-chlorobenzo[6]thiophene (2.00 g, 11.83 mmol) in THF (50 mL) was added dropwise n-BuLi in THF (5.20 mL, 13.01 mmol) at -78 C. Then it was stirred at -50 C for 1 h. Diethyl oxalate (4.32 g, 29.58 mmol) was added to the mixture quickly at -78 C. The mixture was stirred at -50 C for 1 h. It was quenched with acetic acid, diluted with ethyl acetate (200 mL), washed with water and brine, dried with anhydrous Na2S04, and evaporated to give a residue which was washed with petroleum ether to obtain Compound 3A (2.60 g, yield 82%) as a light yellow solid. LCMS: 269 [M+l] +; 1H-NMR (CDC13, 400 MHz) major characteristic peaks: delta (ppm) 1.46 (t, J= 7.6 Hz, 3H), 4.45-4.51 (m, 2H), 7.48 (d, J= 8.8 Hz, 1H), 7.82 (d, J= 8.8 Hz, 1H), 7.92 (s, 1H), 8.37 (s, 1H).

20532-33-6, 20532-33-6 5-Chlorobenzothiophene 11309754, abenzothiophene compound, is more and more widely used in various.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; BRIDGES, Alexander, James; WO2015/42397; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

22720-75-8, 2-Acetylbenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 1 (1.76 g, 12 mmol) and compound 2 (1.76 g, 10 mmol) dissolved in ethanol (20 ml) was added an aqueous solution of potassium hydroxide (1.12 g, 20 mmol) (1.1 ml). The mixture was stirred at room temperature overnight, and water was added to the mixture and precipitates were collected by filtration. The precipitates were washed with water, dissolved in ethyl acetate-THF, and dried over anhydrous magnesium sulfate. Activated charcoal was added to the extract, and the mixture was filtered and the filtrate was concentrated. The residue was triturated from ethyl acetate-isopropyl ether to give compound 3 (2.36 g, 77percent). MS.bul.APCI (m/z): 305/307 ([M+H]+), 22720-75-8

The synthetic route of 22720-75-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tanabe Seiyaku Co, Ltd.; US2006/135597; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4,5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a dry glass reaction tube purged with argon and equipped with a magnetic stir bar were added molecular sieves (3-4 A, 100 mg), aldehyde 3a (46 mg, 0.25 mmol), Pd-gamma-Fe2O3 (24 mg, 5 mol% Pd), and cyclohexane (1 mL) and the sealed tube was heated at 130 C for 24 h. The reaction mixture was decanted with the help of an external magnet and the catalyst was washed with CH2Cl2 (5 x 5 mL). The crude product was purified by dry-flash chromatography (SiO2: hexane) to afford 4a (31 mg, 82%) as a white solid; mp 66-68 C.

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Ajda?i?, Vladimir; Nikoli?, Andrea; Simi?, Stefan; Manojlovi?, Dragan; Stojanovi?, Zoran; Nikodinovic-Runic, Jasmina; Opsenica, Igor M.; Synthesis; vol. 50; 1; (2018); p. 119 – 126;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

95-15-8,95-15-8, Thianaphthene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of benzo[b]thiophene (1.34 g, 10 mmol) in AcOH (10 mL) and DCM (25 mL) was added NBS (1.78 g, 10 mmol) in portions. After stirring overnight at room temperature, the reaction mixture was treated with Na2S03 and water, followed by extraction with EtOAc. The combined organic layers were washed with brine and dried over anhydrous Na2S04. After filtration and concentration, the crude product was purified by column chromatography to give the title compound

As the paragraph descriping shows that 95-15-8 is playing an increasingly important role.

Reference£º
Patent; SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emmerson; CAMPBELL, Una; HANANIA, Taleen, G.; SHAO, Liming; WO2013/119895; (2013); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

Example 3; N2-{-3-[(1-benzothien-3-ylmethyl)amino]-trans-cyclohexyl}-N4,N4- dimethylquinazoline-2, 4-diamine; A solution of N2- (3-amino-t7-ans-cyclohexyl)-N4, N4-dimethyl-quinazoline-2, 4-diamine (0.237 g, 0. 83 mmol, from Example 2b) and benzo [b] thiophene-3-carbaldehyde (0.135 g, 0.83 mmol) in MeOH : DCM (1: 2, containing 1% HOAc, 20 mL) was stirred at ambient temperature for 1.5 h, after which a solution of NaBH3CN (0.104 g, 1.66 mmol) in MeOH (4 mL) was added. The reaction mixture was stirred at room temperature until TLC indicated that starting material was consumed. Methanol (20 mL) was added and the reaction mixture was concentrated. The residue was purified on Si02 eluted with DCM: MeOH (98 : 2) containing 2% Et3N and finally DCM: MeOH (9: 1) containing 2% Et3N to give 0. 310 g (86%) of the title compound. This material was dissolved in MeCN and further purified by HPLC (Eluent A: H20 containing 0. 1% TFA; Eluent B: MeCN ; gradient from 10% to 80% of eluent B) to give 0.200 g (56%) of the title compound. 1HNMR (300.1 MHz, MeOD-d4) 8 7.82 (d, 1H), 7.76 (m, 1H), 7.45 (t, 1H), 7.05-7. 33 (m, 5H), 7.01 (t, 1H), 4.32 (br s, 1H), 3.96 (s, 2H), 3.18 (s, 6H), 2.90 (m, 1H), 1.3-2. 1 (m, 8H). 13CNMR (75.5 MHz, MeOD-d4) 8 164.7, 158. 0,153, 3,140. 7, 138. 5,134. 6,132. 3,128. 7, 128.0, 126.6, 124.2, 123.9, 123.3, 122.5, 121.4, 120. 0, 111.8, 51.9, 46.0, 43.8, 40.9, 36.6, 31.3, 31.2, 19.8. LC-MS [M+H] +432. 2.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2005/70902; (2005); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

360575-29-7, Methyl 4-bromobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 353 mg of methyl 4-bromobenzo[b]thiophene-2-carboxylate, 217 mg of 2-thiophene boronic acid,287 mg of lithium chloride, 248 mg of sodium carbonate, 75 mg of tetrakis(triphenylphosphine)palladium (0), 10 ml of1,4-dioxane, and 5 ml of water was stirred for 3 hours at 100C under a nitrogen atmosphere. After being cooled to roomtemperature, the reaction mixture was concentrated under reduced pressure. Chloroform and water were added to theresidues, and insoluble matter was separated by filtration. The aqueous layer was extracted twice by using chloroform,and the collected organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentratedunder reduced pressure. The residues were subjected to silica gel column chromatography, thereby obtaining 350 mgof methyl 4-(2-thienyl)benzo[b]thiophene-2-carboxylate., 360575-29-7

Big data shows that 360575-29-7 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2926660; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.,4923-87-9

Aluminum trichloride (3.75 g, 28.1 mmol) and dichloromethane (30 mL) were added to a 250 mL single-neck round bottom flask at 0 C. Slowly add acetyl chloride (2.21 g, 28.2 mmol) and stir for half an hour. Then 5-bromobenzothiophene (4.0 g, 18.8 mmol, dissolved in 20 mL of dichloromethane) was added dropwise. The reaction was stirred for half an hour; then transferred to 25 C for 2 hours. Quench slowly by adding water (50 mL), and separate the liquid. The organic phase was washed again with saturated sodium bicarbonate solution (50 mL¡Á3). The organic phase was collected, dried over anhydrous sodium sulfate (2 g), filtered. The filtrate was depressurized and dried. The title compound was obtained as a yellow solid (4.41 g, 92.2%).

The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhong Wenhe; Jin Chuanfei; Xu Tengfei; (39 pag.)CN109796447; (2019); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem