20532-33-6, 5-Chlorobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of Br2 (160 mg, 1.00 mmol) in methylene chloride (5 mL) was added dropwise to a 25 mL round bottom flask charged with 5-chlorobenzo[b]thiophene (169 mg, 1.00 mmol), and NaOAc (164 mg, 2.00 mmol) in methylene chloride (10 mL) at 0 C. over 5 min. The resulting mixture was added dropwise into boiling polyphosphoric acid (1 g) in chlorobenzene (5 mL) over 5 min. Work-up: the mixture was poured into 10% aqueous solution of NaHSO3 (20 mL), extracted three times with EtOAc (20 mL), and dried over MgSO4. The mixture was concentrated to give the title compound in 0.247 g (99% yield) as a pale yellow solid (mp 84 C.). 1H-NMR (300 MHz, DMSO-d6): delta:: 7.45-7.56 (m, 1H), 7.76-7.77 (d, 1H), 7.99-8.18 (m, 2H), 20532-33-6
20532-33-6 5-Chlorobenzothiophene 11309754, abenzothiophene compound, is more and more widely used in various.
Reference£º
Patent; Kahraman, Mehmet; Borchardt, Allen J.; Cook, Travis G.; Davis, Robert L.; Gardiner, Elizabeth M.M.; Malecha, James W.; Noble, Stewart A.; Prins, Thomas J.; US2008/21026; (2008); A1;,
Benzothiophene – Wikipedia
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