6314-28-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.
benzo[b]thiophene-2-carboxylic acid ( 159 mg , 0.892 mmol ) ,2-amino-biphenyl (156 mg, 0.922 mmol), DCC (393 mg, 1.90mmol) and DMAP ( 26 mg , 0.21 mmol) dissolved in dichloromethane (20 mL) and stirred for 14 hours at room temperature .When confirmation thin layer chromatography (TLC), when a new spot is generated , and then adding water to the reaction mixture , dichloromethane coming And extracted twice with . The extracted organic layer was dried over magnesium sulfate and concentrated under reduced pressure. It was purified by column chromatography (silica gel , ethyl acetate / n- hexane = 1/9 ) to obtain the object compound ( 102 mg , 35 % ) as a white solid
The synthetic route of 6314-28-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Korea Research Instituteof Chemical Technology; Jong, Yeong Sik; Kim, Pil Ho; Han, Soo Bong; Achari, Ragavendra; Kim, Mi Hyeon; Lee, Jong Kyo; Shin, Jin Soo; (128 pag.)KR2015/134301; (2015); A;,
Benzothiophene – Wikipedia
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