With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.
Example 4: Synthesis o -(benzothiophen-2-yl)-2-hydroxyethylsulfamide[0097] 2-Amino-l-benzo[b]thiophen-2-yl-ethanol hydrochloride salt. To a stirring solution of benzo[b]thiophene-2-carbaldehyde (1.0 g, 6.16 mmol) and trimethylsilyl cyanide (0.92 mL, 6.78 mmol) in dichloromethane (8 mL) at room temperature under nitrogen was added a few crystals of zinc iodide. The mixture was stirred at this temperature for 20 hours and concentrated. The residue was dissolved in borane in tetrahydrofuran (1M, 13.6 mL) and heated to reflux for 5 hours. The mixture was cooled to room temperature and concentrated. The syrup was dissolved in methanol (25 mL), treated with hydrogen chloride (4M in dioxane, 6.8 mL), and heated to reflux for 2 hours, and then concentrated. The solid obtained was dissolved in hydrochloric acid (2N, 10 mL) and extracted twice with diethyl ether. The aqueous solution was concentrated, crystallized from methanol/ether, and dried in vacuum oven to give a yellow (770 mg,54%)., 3541-37-5
As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.
Reference£º
Patent; ADVANCED NEURAL DYNAMICS, INC.; FOX CHASE CHEMICAL DIVERSITY CENTER, INC.; SMITH, Garry, Robert; BRENNEMAN, Douglas, Eric; REITZ, Allen, B.; DU, Yanming; WO2011/97337; (2011); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem