Some tips on 6314-28-9

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6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6314-28-9

Benzo[b]thiophene-2-carboxylic Acid [4a-(3-Methoxyphenyl)-8a-methyl-2-(3-phenylpropyl)octahydroisoquinolin-6-yl]amide (25d).; To compound 24 (52 mg, 0.132 mmol) dissolved in anhydrous THF (10 mL) was added benzo[b]thiophene-2-carboxylic acid (35 mg, 0.198 mmol), triethylamine (0.092 mL, 0.662 mmol), and BOP reagent (64 mg, 0.145 mmol), and the reaction mixture was allowed to stir at room temperature for 1.5 h. Reaction was monitored by TLC (30% CMA 80 in CH2Cl2). The reaction mixture was diluted with EtOAc (20 mL) and washed with saturated aqueous NaHCO3 (20 mL) followed by water (20 mL). The aqueous layers were back extracted with EtOAc (2¡Á20 mL). The combined organic layers were washed with 1 N NaOH (25 mL), dried (MgSO4), and concentrated under reduced pressure to afford crude product. The crude product was purified by flash chromatography (20% CMA 80 in CH2Cl2) to afford 70 mg (96%): LCMS (ESI): m/z 553.9 (M+H)+; 1H NMR (CDCl3, 300 MHz) delta 7.74-7.81 [m, 3H], 7.36-7.40 [m, 2H], 7.18-7.31 [m, 7H], 6.74-6.75 [m, 1H], 6.12 [d, J=9 Hz, 1H], 4.47 [m, 1H], 3.81 [s, 3H], 2.76-2.79 [br, 1H], 2.59-2.67 [m, 3H], 2.36-2.39, [m, 2H], 2.15-2.29 [m, 4H], 1.89-1.94 [m, 3H], 1.60-1.81 [m, 4H], 1.53 [d, J=12 Hz, 1H], 1.26-1.32 [m 1H], 1.24 [s, 3H]; 13C NMR (CDCl3, 300 MHz) delta 161.9, 159.3, 148.7, 142.8, 141.2, 139.5, 139.2, 128.9, 128.8, 128.7, 126.6, 126.1, 125.3, 125.2, 123.1, 122.0, 116.4, 110.8, 62.3, 58.3, 55.6, 51.2, 47.1, 44.4, 38.1, 37.0, 36.8, 35.6, 34.0, 29.2, 28.3, 26.7.

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Reference£º
Patent; Research Triangle Institute; US2007/27182; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem