351005-12-4, 5-Bromo-1,3-dihydrobenzo[c]thiophene 2,2-dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,351005-12-4
5-bromo-1 ,3-dihydro-2-benzothiophene-2,2-dione (475 mg, 1.92 mmol)and freshly prepared bromo[1-(methoxycarbonyl)cyclopropyl]zinc (4.81 mL, 3.84mmol) were dissolved in dry THF (5 mL) and the solution was degassed by nitrogen bubbling for 5 mm. Then, XPhos (183 mg, 0.38 mmol) and Pd2(dba)3 (176 mg, 0.19 mmol) were incorporated and the reaction mixture was stirred at75C for lh. The mixture was cooled to rt and quenched with water and extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered and the solution was concentrated to dryness. The crude was adsorbed onto silica gel and purified by column chromatography eluting with a gradient of Cyclohexane/EtOAc from [90:10] to [60:40]. The product fractions were combined and concentrated to dryness to afford a white solid. The solid was triturated with cyclochexane and dried under vacuum at 40C to constant weight to afford methyl 1 -(2,2-dioxo-1 ,3-d ihyd ro-2-benzoth iophen-5-yl)cyclopropane-1 – carboxylate Ex.43a (254 mg, 50%) as white solid. 1 H NMR (300 MHz, DMSOd6, din ppm): 1.18-1.22 (m, 2H), 1.47-1.51 (m, 2H), 3.54 (s, 3H), 4.46 (s, 4H),7.29-7.35 (m, 3H).
351005-12-4 5-Bromo-1,3-dihydrobenzo[c]thiophene 2,2-dioxide 288396, abenzothiophene compound, is more and more widely used in various.
Reference£º
Patent; GENFIT; DELHOMEL, Jean-Francois; PERSPICACE, Enrico; MAJD, Zouher; PARROCHE, Peggy; WALCZAK, Robert; (284 pag.)WO2018/138362; (2018); A1;,
Benzothiophene – Wikipedia
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