With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20532-33-6,5-Chlorobenzothiophene,as a common compound, the synthetic route is as follows.
Unless otherwise specified, under an inert atmosphere C1 (31.9mg, 0.04 mmol, 10 mol %), aryl halide (0.4 mmol), boronic acid(1.2 mmol), and KOtBu (157.1 mg, 1.4 mmol), were added to anoven-dried 4 dram vial containing a magnetic stir bar. 1,4-Dioxane (4 mL) and EtOH (101.7 muL) were added. The vial wassealed with a screwcap featuring a PTFE/silicone septum andwas removed from the glovebox. The reaction mixture wasmagnetically stirred for 16 h in a temperature-controlled aluminumheating block set to 60 C. After 16 h, the reactionmixture was cooled to room temperature, taken up in EtOAc (ca.10 mL), and extracted with distilled water (3 ¡Á 10 mL). Theorganic layer was dried over anhydrous Na2SO4, filtered, andconcentrated with the aid of a rotary evaporator., 20532-33-6
The synthetic route of 20532-33-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Sawatzky, Ryan S.; Stradiotto, Mark; Synlett; vol. 29; 6; (2018); p. 799 – 804;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem