20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20699-85-8
A solution of 4-((ieri-butoxycarbonyl)amino)-i-methyl-iH-pyrrole-2-carboxylic acid (500 mg, 2.1 mmol) in A V-dimethylformamide (10 mL) was charged with i-(3- dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (725 mg, 3.8 mmol) and 4- (dimethylamino)pyridine (577 mg, 4.7 mmol). The reaction mixture was stirred at room temperature for 2 h. Methyl 5-aminobenzo[]thiophene-2-carboxylate 17 (392 mg, 1.9 mmol) was then added and the resulting mixture was stirred at room temperature for 16 h. This was then poured into ice-water (20 mL) and extracted with ethyl acetate (3 x 50 mL). The combined organic extracts were sequentially washed with 1 M citric acid (30 mL), a saturated aqueous solution of sodium hydrogen carbonate (35 mL), water (35 mL) and brine (35 mL). The organic layer was then dried over sodium sulfate, filtered and concentrated. The resulting residue was purified by column chromatography (silica), eluting with ethyl acetate/hexane (from 0% to 50%), to give the title compound 18 (610 mg, 75%) as a beige solid. (0901) MS (ES+): m/z = 430 (M+H)+; LCMS: tR = 7.90 min.
The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FEMTOGENIX LIMITED; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; JACKSON, Paul Joseph Mark; (137 pag.)WO2016/198869; (2016); A1;,
Benzothiophene – Wikipedia
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