Downstream synthetic route of 20532-28-9

The synthetic route of 20532-28-9 has been constantly updated, and we look forward to future research findings.

20532-28-9, 5-Aminobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20532-28-9

EXAMPLE 61 Benzo[b]thiophen-5-yl-(6-methyl-pyrido[3,4-d]pyrimidin-4-yl)-aminehydrochloride This material was prepared from 6-methyl-pyrido[3,4-d]pyrimid -4-one (1.0 eq.) and 5-amino-benzo[b]thiophene (1.5 eq.) as described for Example 60. The polymer was filtered off and washed several times with 30% methanol/70% chloroform. Triethylamine (3.0 eq) was added to the filtrate and washings before they were concentrated in vacuo. The residue was flash chromatographed on silica in 10% methanol/methylenechloride to afford 135 mg of product as the free base (LC-MS: 293(MH+)). This material was dissolved in a minimum volume of chloroform and 1 mole equivalent of HCl in ether was added dropwise with stirring. The reaction mixture was diluted with ether (4volumes) and the precipitated title product was filtered and dried in vacuo (152 mg; M.P. 273-276 C.; LC-MS: 293 (MH+); anal. RP-HPLC:4.10 min.).

The synthetic route of 20532-28-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US6395733; (2002); B1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem