With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20532-28-9,5-Aminobenzothiophene,as a common compound, the synthetic route is as follows.
A solution of 540 mg of benzo[b]thiophen-5-ylamine in 5 ml of diethyl ethoxymethylenemalonate is stirred at 130C for 1.5 hours. The reaction mixture is then diluted with ethyl acetate. It is washed with saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated in vacuo. The crude product is purified by column chromatography on silica gel with a hexane/ethyl acetate mixture. 1.88 g of product are obtained.1H-NMR (CDCl3): delta= 1.30-1.45 (6H); 4.20-4.38 (4H); 7.16 (1 H); 7.30 (1 H); 7.51 (1H); 7.58 (1H); 7.86 (1 H); 8.60 (1H) 11.12 (1 H).
As the paragraph descriping shows that 20532-28-9 is playing an increasingly important role.
Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; WO2007/147578; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem