With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-32-9,6-Bromobenzothiophene,as a common compound, the synthetic route is as follows.
Compound TDI01106-1 (2.50 g, 7.04 mmol) and cuprous cyanide (1.58 g, 17.6 mmol) were dissolved in Nmethylpyrrolidone(25 mL), the reaction was performed under microwave radiation at 200C for 1 hour. Thin layerchromatography (petroleum ether : ethyl acetate=5: 1) indicated the reaction was complete. The reaction solution wascooled to room temperature, followed by addition of water (100 mL), and was extracted with ethyl acetate (50 mL X 3).The combined organic phase was washed with saturated brine (80 mL X 3), dried over anhydrous sodium sulfate, filtered,concentrated under reduced pressure, and the residue was purified by column chromatography (petroleum ether : ethylacetate= 20:1), to afford compound TDI01106-2 (1.00 g, yellow solid, yield: 54.1%).1H NMR (400 MHz, CDCl3) delta 8.22 (s, 1H), 7.90 (d, J = 8.4 Hz, 1H), 7.72 (d, J = 5.6 Hz, 1H), 7.60 (dd, J = 8.4, 1.2 Hz,1H), 7.42 (d, J = 5.6 Hz, 1H).
The synthetic route of 17347-32-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Beijing Tide Pharmaceutical Co., Ltd.; Zhao, Yanping; Wang, Hongjun; Li, Gong; Jiang, Yuanyuan; Li, Xiang; Zhou, Liying; Liu, Yanan; (235 pag.)EP3421465; (2019); A1;,
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