With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.
1 g of 4-bromophenylacetonitrile (5.1 mmol) and 825 mg ofbenzo[b]thiophene-2-carboxaldehyde (5.1 mmol) were dissolvedin dry MeOH (30 mL) and stirred at 0 C for 5 min 380 mg of odium methoxide (7.1 mmol) were added in small portions, and themixture was stirred for 15 min at 0 C and then for 4 h at roomtemperature. The resulting precipitate was collected using a sinteredglass filter, washed with 10 mL of MeOH, then with water anddried to give 1.56 g of the alpha,beta-unsaturated nitrile 7 as a yellow solid(90%); Rf 0.36 (cyclohexane/EtOAc, 90:10); m.p 160-162 C ; 1HNMR (300 MHz, CDCl3): d (ppm): 7.37-7.45 (m, 2H), 7.52-7.60 (m,4H), 7.69 (s, 1H, Hvinyl), 7.82-7.87 (m, 3H); 13C NMR (75 MHz,CDCl3): delta(ppm): 109.68 (C), 117.35 (CN), 122.43 (CH), 123.58 (C),124.65 (CH), 125.12 (CH), 126.67 (CH), 127.33 (2CH), 130.01 (CH),132.31 (2CH) 132.86 (C), 134.86 (CH), 137.37 (C), 138.69 (C), 141.28(C); HRMS (MALDI-TOF) Calcd for (C17H10BrNS): [M]+: 338.9717.Found: 338.9711.
3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various.
Reference£º
Article; Hafedh, Nesrine; Aloui, Faouzi; Raouafi, Sondes; Journal of Molecular Structure; vol. 1165; (2018); p. 126 – 131;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem