With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.
Step 1: A solution of benzo [b]thiophene-2-carbaldehyde (1.0 g, 6.17 mmol) and carbon tetrabromide (3.1 g, 9.25 mmol) in methylene chloride (50 mL) was cooled to 0C. A solution of triphenylphosphine (4.86 g, 18.3 mmol) in methylene chloride (20 mL) was added dropwise. After 1/2 hour the solution was placed on a plug of silica gel and eluted with 20% ethyl acetate: hexane. Concentration of the eluent resulted in the isolation of 1.3 g (67%) of 2- (2, 2-Dibromo-vinvl)-benzofblthiophene as a yellow oil, which was used as such in the next step.
The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; WYETH; WO2005/37807; (2005); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem